| | 101626-70-4 Basic information More.. |
| Product Name: | TALIPEXOLE | | Synonyms: | TALIPEXOLE;5，6，7，8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4，5-d]azepin-2-amine;Domin;6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine;6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine;Talipexol;Talipexol [spanish];Talipexolum | | CAS: | 101626-70-4 | | MF: | C10H15N3S | | MW: | 209.31 | | EINECS: | | | Mol File: | 101626-70-4.mol |  |
Use
Domin was launched in Japan for Parkinson's disease. The compound is
readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its
antiparkinson activity resides in the fact that talipexole is a selective agonist for
presynaptic dopamine D2 receptors with no D1 receptor activity. It is a clonidine-like α2-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most
widely used dopamine angonist. Also it is 70 times more potent than bromocriptine
and has a more rapid onset of action. In addition to its anti-tremor activity there was
a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT3
receptor antagonistic activity. Its metabolites have no biological activity, there was
no development of tolerence and its effect could be enhanced by L-dopa.
- Talipexole
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- US $2500.00-1980.00 / mg
- 2024-10-28
- CAS:101626-70-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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101626-70-4
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