ChemicalBook CAS DataBase List FLUSPIRILENE

FLUSPIRILENE synthesis

2synthesis methods

Product Name:FLUSPIRILENE
CAS Number:1841-19-6
Molecular formula:C29H31F2N3O
Molecular Weight:475.57

Fluspirilene, 8-[4,4-bis(p-fluorophenyl)butyl]-1-phenyl-1,3,8-triazaspiro [4,5]decan-4-one (6.6.9), is synthesized from 1-benzyl-4-anilino-4-cyanopiperidine (3.1.64) by the way of its acidic hydrolysis into the amide (6.6.6), and the subsequent heterocyclization of 4-aminocarbonyl and 4-aniline functional groups into imidazolone cycle, thus creating the desired spiroheterocyclic system, 8-benzyl-1-phenyl-1,3,8-triazaspiro[4,5] decan-4-one (6.6.7). Hydrogenation of this product using a palladium on carbon catalyst removes the N-benzyl protecting group, forming 1-phenyl-1,3,8-triazaspiro [4,5]decan-4-one (6.6.8). Alkylating this with 1,1-bis-(4-fluorophenyl)butyl bromide (6.6.3) gives fluspirilene (6.6.9) [64–66].

1,1'-(4-bromobutylidene)bis[4-fluorobenzene]

57668-61-8
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1-PHENYL-1,3,8-TRIAZASPIRO[4.5]DECAN-4-ONE

1021-25-6
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1841-19-6
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$55.00/5mg

1,3,8-Triazaspiro[4.5]decan-4-one, 8-[4,4-bis(4-fluorophenyl)-3-buten-1-yl]-1-phenyl-

1841-17-4
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1841-19-6
91 suppliers
$55.00/5mg

References

FLUSPIRILENE Related Search:

1-Methyl-4-(methylamino)piperidine 4-(Aminomethyl)piperidine N,N-Dimethylpiperidin-4-amine Isonipecotamide (1-Methyl-4-piperidinyl)methanamine 2-methyl-1,4-diaminobutane N-phenylpiperidin-4-amine 1-METHYLPIPERIDINE-4-CARBOXAMIDE 4-AMINO-1-(1-PROPYL)-PIPERIDINE N-(2-amino-1,1-dimethylethyl)-N,N-dimethylamine

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FLUSPIRILENE synthesis

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