1-[3-(4-Bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea manufacturers
- Nelotanserin
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- $34.00 / 1mg
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2024-11-19
- CAS:839713-36-9
- Min. Order:
- Purity: 98.42%
- Supply Ability: 10g
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| | 1-[3-(4-Bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea Basic information |
| | 1-[3-(4-Bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea Chemical Properties |
| Boiling point | 425.9±45.0 °C(Predicted) | | density | 1.55±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:32.0(Max Conc. mg/mL);73.2(Max Conc. mM) | | form | Solid | | pka | 12.29±0.70(Predicted) | | color | White to off-white |
| | 1-[3-(4-Bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea Usage And Synthesis |
| Uses | Nelotanserin is a potent selective 5-HT2A inverse agonist, nelotanserin has low nanomolar potency on the 5-HT2A receptor with at least 30- and 5000-fold selectivity compared with 5-HT2C and 5-HT2B receptors. | | Definition | ChEBI: Nelotanserin is a member of pyrazoles and a ring assembly. | | in vivo | Each compound is tested in a minimum of five rats by oral gavage with administration occurring in the middle of the inactive period, 6 h after light onset. The delta power during non-REM sleep (NREMS) is significantly different between all the analogues tested and the vehicle control. Nelotanserin (Compound 39) produces significant increases in delta power that persist for the first 4 h following dosing. Significant differences are found, however, in NREMS bout length. Nelotanserin significantly increases NREMS bout length during the first hour following dosing, and 3 does so during the second hour. In conjunction with this increased NREM bout duration, the number of NREM bouts decrease during the first hour for Nelotanserin (p<0.01) as well as for compound 15 (p<0.05)[2]. | | IC 50 | 5-HT2A Receptor: 1.7 nM (IC50); 5-HT2C Receptor: 79 nM (IC50); 5-HT2B Receptor: 791 nM (IC50) |
| | 1-[3-(4-Bromo-1-methyl-1H-pyrazol-5-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea Preparation Products And Raw materials |
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