| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:IRAK4-IN-13
CAS:2667681-57-2
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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Pyrido[3,2-d]pyrimidin-2-amine, 4-[(1-methylcyclopropyl)oxy]-N-[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]-6-(5-pyrimidinyl)- manufacturers
- IRAK4-IN-13
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- $1980.00 / 50mg
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2025-04-28
- CAS:2667681-57-2
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Pyrido[3,2-d]pyrimidin-2-amine, 4-[(1-methylcyclopropyl)oxy]-N-[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]-6-(5-pyrimidinyl)- Basic information |
| | Pyrido[3,2-d]pyrimidin-2-amine, 4-[(1-methylcyclopropyl)oxy]-N-[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]-6-(5-pyrimidinyl)- Chemical Properties |
| Boiling point | 698.4±65.0 °C(Predicted) | | density | 1.46±0.1 g/cm3(Predicted) | | pka | 8.53±0.10(Predicted) |
| | Pyrido[3,2-d]pyrimidin-2-amine, 4-[(1-methylcyclopropyl)oxy]-N-[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]-6-(5-pyrimidinyl)- Usage And Synthesis |
| Uses | IRAK4-IN-13 (compound 21) is a potent and selective IRAK4 inhibitor with an IC50 of 0.6 nM. IRAK4-IN-13 shows high metabolic clearance with human liver microsomes (HLM) intrinsic clearance is 96 μL/min/mg[1]. | | IC 50 | IRAK4: 0.6 nM (IC50) | | References | [1] Degorce SL, et al. Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors. Bioorg Med Chem. 2020 Dec 1;28(23):115815. DOI:10.1016/j.bmc.2020.115815 |
| | Pyrido[3,2-d]pyrimidin-2-amine, 4-[(1-methylcyclopropyl)oxy]-N-[1-(1-methyl-4-piperidinyl)-1H-pyrazol-4-yl]-6-(5-pyrimidinyl)- Preparation Products And Raw materials |
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