DIBROMOACETIC ACID manufacturers
- DIBROMOACETIC ACID
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- $1.00 / 1KG
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2020-02-04
- CAS:631-64-1
- Min. Order: 1KG
- Purity: Min98% HPLC
- Supply Ability: g/kg/ton
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| | DIBROMOACETIC ACID Basic information |
| | DIBROMOACETIC ACID Chemical Properties |
| Melting point | 32-38 °C (lit.) | | Boiling point | 128-130 °C/16 mmHg (lit.) | | density | 2.382 g/mL at 25 °C (lit.) | | refractive index | 1.5220 (estimate) | | Fp | >230 °F | | storage temp. | room temp | | solubility | DMSO : 100 mg/mL (459.05 mM; Need ultrasonic) | | form | Solid | | pka | pK1:1.39 (25°C) | | color | White to off-white | | BRN | 1700457 | | Stability: | Hygroscopic | | IARC | 2B (Vol. 101) 2013 | | EPA Substance Registry System | Dibromoacetic acid (631-64-1) |
| | DIBROMOACETIC ACID Usage And Synthesis |
| Uses | Dibromoacetic acid (Br2CHCOOH, CAS Number 631-64-1) may be used as an analytical reference standard for the determination of the analyte in aqueous samples by various chromatographic techniques. | | Definition | ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are replaced by bromo groups. | | General Description | Dibromoacetic acid belongs to the category of haloacetic acids (HAAs) which are a class of disinfection by-products produced in water. | | in vivo | There is some evidence of carcinogenic activity of Dibromoacetic acid in male rats based on an increased incidence of malignant mesothelioma. The increased incidences of mononuclear cell leukemia in male rats may have been related to Dibromoacetic acid exposure[2].
There is some evidence of carcinogenic activity of Dibromoacetic acid in female rats based on an increased incidence and positive trend of mononuclear cell leukemia[2].
There is clear evidence of carcinogenic activity of Dibromoacetic acid in male and female mice based on increased incidences of hepatocellular neoplasms and hepatoblastoma (males only). Increased incidences of lung neoplasms in male mice were also considered to be exposure related[2]. | Animal Model: | Male and female F344/N rats and B6C3F1 mice[2] | | Dosage: | Groups of five male and five female rats/mice were exposed to 0, 125, 250, 500, 1,000, or 2,000 mg/L Dibromoacetic acid in drinking water for 2 weeks
Groups of 10 male and 10 female rats/mice were exposed to 0, 125, 250, 500, 1,000, or 2,000 mg/L Dibromoacetic acid in drinking water for 3 months
Groups of 50 male and 50 female rats/mice were exposed to drinking water containing 0, 50, 500, and 1,000 mg/L Dibromoacetic acid for 2 years
| | Administration: | Exposed to Dibromoacetic acid (greater than 99% pure) in drinking water for 2 weeks, 3 months, or 2 years. | | Result: | Exposure to Dibromoacetic acid for 2 years caused increased incidences of cystic degeneration of the liver in male rats, increased incidences of alveolar epithelial hyperplasia and nephropathy in female rats, and increased incidences of splenic hematopoiesis in male mice. |
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| | DIBROMOACETIC ACID Preparation Products And Raw materials |
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