Necrostatin-2 S enantioMer manufacturers
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| | Necrostatin-2 S enantioMer Basic information |
| Product Name: | Necrostatin-2 S enantioMer | | Synonyms: | Necrostatin 2 (S enantioMer);Necrostatin-2 S enantioMer;(5S)-5-[(7-Chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione;2,4-Imidazolidinedione, 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-, (5S)- | | CAS: | 852391-20-9 | | MF: | C13H12ClN3O2 | | MW: | 277.71 | | EINECS: | | | Product Categories: | | | Mol File: | 852391-20-9.mol |  |
| | Necrostatin-2 S enantioMer Chemical Properties |
| density | 1.450±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 50 mg/mL (180.04 mM; Need ultrasonic) | | form | Powder | | pka | 8.48±0.70(Predicted) | | color | White to light yellow |
| | Necrostatin-2 S enantioMer Usage And Synthesis |
| Uses | Necrostatin 2 S enantiomer is the S enantiomer of Necrostatin 2. Necrostatin 2 is a potent necroptosis inhibitor, acts as a RIPK1 inhibitor lacking the IDO-targeting effect.
Target: RIPK1 [4]
Necrostatin 2 is a potent in vitro necroptosis inhibitors (exemplified by 1, EC50-0.05 uM) that also were efficacious in an animal model of ischemic stroke. Many Necroptosis inhibitor derivatives are designed for researchers.
Necroptosis is a regulated caspase-independent cell death mechanism that results in morphological features resembling necrosis. It can be induced in a FADD-deficient variant of human Jurkat T cells treated with TNF-a. 5-(1H-Indol-3-ylmethyl)-2-thiohydantoins and 5-(1H-indol-3-ylmethyl)hydantoins were found to be potent necroptosis inhibitors (called necrostatins). | | References | [1] Teng X, Keys H, Jeevanandam A, Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6836-40. DOI:10.1016/j.bmcl.2007.10.024
[2] Takahashi N, et al. Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models. Cell Death Dis. 2012 Nov 29;3:e437. DOI:10.1038/cddis.2012.176
[3] Jagtap PG, Degterev A, Choi S, Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19;50(8):1886-95. DOI:10.1021/jm061016o
[4] Teng X, Degterev A, Jagtap P, Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15;15(22):5039-44. DOI:10.1016/j.bmcl.2005.07.077 |
| | Necrostatin-2 S enantioMer Preparation Products And Raw materials |
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