- Azido-PEG3-Tos
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- $0.00 / 1g
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2024-03-24
- CAS:178685-33-1
- Min. Order: 1g
- Purity: >98.00%
- Supply Ability: 1g
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| | Azide-PEG3-Tos Basic information |
| Product Name: | Azide-PEG3-Tos | | Synonyms: | Azide-PEG3-Tos;N3-PEG3-Tos;Azido-PEG3-Ots;Ethanol, 2-[2-(2-azidoethoxy)ethoxy]-, 4-methylbenzenesulfonate (ester);N3-PEG3-OTs;2-(2-(2-Azidoethoxy)ethoxy)ethyl 4-methylbenzenesulfonate;Toluene-4-sulfonic acid 2-[2-(2-azido-ethoxy)-ethoxy]-ethyl ester;N3-PEG3-Tos/Ethanol, 2-[2-(2-azidoethoxy)ethoxy]-, 1-(4-methylbenzenesulfonate) | | CAS: | 178685-33-1 | | MF: | C13H19N3O5S | | MW: | 329.37 | | EINECS: | | | Product Categories: | peg | | Mol File: | 178685-33-1.mol |  |
| | Azide-PEG3-Tos Chemical Properties |
| solubility | Soluble in DMSO, DCM, DMF | | form | Liquid | | color | Colorless to light yellow |
| | Azide-PEG3-Tos Usage And Synthesis |
| Description | Azide-PEG3-Tos is a heterobifunctional PEG linker.The azide (N3) group is reactive with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. Tosyl group is a good leaving group for nucleophilic substitution reactions. | | Uses | Azide-PEG3-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azide-PEG3-Tos is also a non-cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. Azide-PEG3-Tos is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | | IC 50 | PEGs; Non-cleavable Linker | | References | [1] Borchmann DE, et al. GRGDS-Functionalized Poly(lactide)-graft-poly(ethylene glycol) Copolymers: Combining Thiol-Ene Chemistry with Staudinger Ligation. Macromolecules. 2013 Jun 11;46(11):4426-4431. DOI:10.1021/ma4005633
[2] Park, Tae Kyo, et al. Compound bearing beta-galactoside-introduced self-immolative linker. WO2018124758A2. |
| | Azide-PEG3-Tos Preparation Products And Raw materials |
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