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TargetMol Chemicals Inc.
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Product Name:LBT 999 CAS:877467-20-4 Package:25mg/RMB 12800;100mg/RMB 21500;50mg/RMB 16800
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8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-buten-1-yl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)- manufacturers
- LBT 999
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- $1820.00 / 25mg
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2024-10-28
- CAS:877467-20-4
- Min. Order:
- Purity:
- Supply Ability: 10g
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| 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-buten-1-yl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)- Basic information |
Product Name: | 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-buten-1-yl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)- | Synonyms: | 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-buten-1-yl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)-;LBT 999;LBT999;LBT-999 | CAS: | 877467-20-4 | MF: | C20H26FNO2 | MW: | 331.42 | EINECS: | | Product Categories: | | Mol File: | 877467-20-4.mol | ![8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-buten-1-yl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)- Structure](CAS/20200515/GIF/877467-20-4.gif) |
| 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-buten-1-yl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)- Chemical Properties |
| 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-buten-1-yl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)- Usage And Synthesis |
Uses | LBT-999 is a phenyltropane derivative used for positron emission tomography (PET) exploration of the dopamine transporter (DAT). It has high affinity binding to DAT on rat striatal membranes and human postmortem brain slices in vitro, high uptake in the striatum in rat and baboon models in vivo, and its binding can be blocked by specific compounds. | References | [1] Pharmacological characterization of (E)-N-(4-fluorobut-2-enyl)-2beta-carbomethoxy-3beta-(4'-tolyl)nortropane (LBT-999) as a highly promising fluorinated ligand for the dopamine transporter |
| 8-Azabicyclo[3.2.1]octane-2-carboxylic acid, 8-[(2E)-4-fluoro-2-buten-1-yl]-3-(4-methylphenyl)-, methyl ester, (1R,2S,3S,5S)- Preparation Products And Raw materials |
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