| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:2-chloro Palmitic Acid
CAS:19117-92-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:2-chloro Palmitic Acid
CAS:19117-92-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
4008200310 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:2-chloro Palmitic Acid
CAS:19117-92-1
Package:1mg/RMB 1080;5mg/RMB 3930;10mg/RMB 7330
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2-chloro Palmitic Acid manufacturers
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| | 2-chloro Palmitic Acid Basic information |
| | 2-chloro Palmitic Acid Chemical Properties |
| Melting point | 52-53 °C | | Boiling point | 394.6±15.0 °C(Predicted) | | density | 0.972±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml | | form | A crystalline solid | | pka | 2.97±0.21(Predicted) | | color | White to off-white |
| | 2-chloro Palmitic Acid Usage And Synthesis |
| Description | 2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate (PMA; ). 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli.1 It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM.2,3 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.4 | | Uses | 2-Chlorohexadecanoic acid, an inflammatory lipid mediator, interferes with protein palmitoylation,induces ER-stress markers, reduced the ER ATP content, and activates transcription and secretion of IL-6 as well as IL-8.2-Chlorohexadecanoic acid disrupts the mitochondrial membrane potential and induces procaspase-3 and PARP cleavage.2-Chlorohexadecanoic acid can across blood-brain barrier (BBB) and compromises ER- and mitochondrial functions in the human brain endothelial cell line hCMEC/D3[1]. | | References | 1. Palladino, E.N.D., Katunga, L.A., Kolar, G.R., et al. 2-Chlorofatty acids: Lipid mediators of neutrophil extracellular trap formation J. Lipid. Res. 59(8),1424-1432(2018).
2. Messner, M.C., Albert, C.J., and Ford, D.A. 2-Chlorohexadecanal and 2-chlorohexadecanoic acid induce COX-2 expression in human coronary artery endothelial cells Lipids 43(7),581-588(2008).
3. Hartman, C.L., Duerr, M.A., Albert, C.J., et al. 2-Chlorofatty acids induce Weibel-Palade body mobilization J. Lipid. Res. 59(1),113-122(2018).
4. Wang, W.Y., Albert, C.J., and Ford, D.A. α-Chlorofatty acid accumulates in activated monocytes and causes apoptosis through reactive oxygen species production and endoplasmic reticulum stress Arterioscler. Thromb. Vasc. Biol. 34(3),526-532(2014). |
| | 2-chloro Palmitic Acid Preparation Products And Raw materials |
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