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Postion:Product Catalog >Anticancer agent 47
Anticancer agent 47
  • Anticancer agent 47

Anticancer agent 47 NEW

Price $1520 $1980 $2500
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-04-28

Product Details

Product Name: Anticancer agent 47 CAS No.: 2461795-23-1
Supply Ability: 10g Release date: 2025/04/28

Product Introduction

Bioactivity

NameAnticancer agent 47
DescriptionAnticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities, inducing apoptosis, and causing cell cycle arrest at the G0/G1 phase. Moreover, Anticancer agent 47 has shown significant in vivo antitumor activities [1].
In vitroAnticancer agent 47 (compound 4j) exhibits antiproliferative activity with IC50 values of 1.6, 0.72, and 7.07 μM for HepG2, A549, and H596 cells, respectively [1]. At concentrations of 0.8, 1.6, and 3.2 μM for 24 h, it induces apoptosis and cell cycle arrest at the G0/G1 phase [1]. At 5 μM for 5 h, it significantly increases ROS production [1]. Apoptosis analysis for HepG2 and H596 cells at 0.8, 1.6, and 3.2 μM for 24 h resulted in apoptotic cell rates of 14.23%, 20.47%, and 27.66%, respectively. Cell cycle analysis for HepG2 cells revealed 48.54%, 49.60%, and 53.00% of cells at G0/G1 phase at 0.6, 1.2, and 2.4 μM, respectively [1].
In vivoAnticancer agent 47, administered intravenously at a dosage of 20 mg/kg every other day for 19 days, demonstrates significant antitumor activities in BALB/c nude mice bearing HepG2 xenografts. This regimen effectively inhibited tumor growth, achieving a tumor inhibition rate of 58.7%.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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