Anticancer agent 47 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: Anticancer agent 47 | CAS No.: 2461795-23-1 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | Anticancer agent 47 |
| Description | Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities, inducing apoptosis, and causing cell cycle arrest at the G0/G1 phase. Moreover, Anticancer agent 47 has shown significant in vivo antitumor activities [1]. |
| In vitro | Anticancer agent 47 (compound 4j) exhibits antiproliferative activity with IC50 values of 1.6, 0.72, and 7.07 μM for HepG2, A549, and H596 cells, respectively [1]. At concentrations of 0.8, 1.6, and 3.2 μM for 24 h, it induces apoptosis and cell cycle arrest at the G0/G1 phase [1]. At 5 μM for 5 h, it significantly increases ROS production [1]. Apoptosis analysis for HepG2 and H596 cells at 0.8, 1.6, and 3.2 μM for 24 h resulted in apoptotic cell rates of 14.23%, 20.47%, and 27.66%, respectively. Cell cycle analysis for HepG2 cells revealed 48.54%, 49.60%, and 53.00% of cells at G0/G1 phase at 0.6, 1.2, and 2.4 μM, respectively [1]. |
| In vivo | Anticancer agent 47, administered intravenously at a dosage of 20 mg/kg every other day for 19 days, demonstrates significant antitumor activities in BALB/c nude mice bearing HepG2 xenografts. This regimen effectively inhibited tumor growth, achieving a tumor inhibition rate of 58.7%. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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