Azelaoyl PAF NEW
| Price | Get Latest Price | ||
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-06-16 |
Product Details
| Product Name: Azelaoyl PAF | CAS No.: 354583-69-0 |
| Supply Ability: 10g | Release date: 2025/06/16 |
Product Introduction
Bioactivity
| Name | Azelaoyl PAF |
| Description | Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones with potency comparable to rosiglitazone. In atherosclerosis studies, Azelaoyl PAF promotes the uptake of oxidized low-density lipoprotein (oxLDL) by macrophages by upregulating CD36 expression. In fibroblasts from Friedreich's ataxia (FRDA) patients, Azelaoyl PAF significantly increased mRNA and protein levels of ferritin. |
| In vitro | Methods: Human neuroblastoma cells SKNBE and primary fibroblasts from skin biopsies of patients with Friedreich's ataxia (FRDA) and healthy controls were treated with the PPAR-γ agonist azelaoyl PAF. Results: Azelaoyl PAF significantly increased intracellular frataxin levels by two-fold in the neuroblastoma cell line SKNBE and fibroblasts from FRDA patients, and azelaoyl PAF increased frataxin via a transcriptional mechanism.[1] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility Information | Ethanol : 10.00 mg/mL (15.34 mM), Sonication is recommended. PBS (pH 7.2) : 6.00 mg/mL (9.20 mM), Sonication is recommended. DMSO : 6.00 mg/mL (9.20 mM), Sonication is recommended. DMF : 20.00 mg/mL (30.68 mM), Sonication is recommended. |
| Keywords | Azelaoyl PAF |
| Inhibitors Related | PHYTOL | Rosiglitazone | Retinoic acid | Cinnamyl alcohol | Daidzein | Fenofibrate | Pioglitazone hydrochloride | 5-Aminosalicylic Acid | Naringenin | Fisetin | 2,3-Butanediol | Icariin |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1800.00/5mg |
VIP3Y
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TargetMol Chemicals Inc.
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2024-11-20 | |
| $15.00/1KG |
Zhuozhou Wenxi import and Export Co., Ltd
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2021-08-11 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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