Closantel NEW
| Price | $34 | $54 | $81 |
| Package | 50mg | 100mg | 200mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-07 |
Product Details
| Product Name: Closantel | CAS No.: 57808-65-8 |
| Purity: 99.76% | Supply Ability: 10g |
| Release date: 2025/05/07 |
Product Introduction
Bioactivity
| Name | Closantel |
| Description | Closantel (R-31520), a salicylanilide anthelmintic compound, shows different anthelmintic spectra and obvious toxicity in mammals. |
| In vitro | Closantel (7.5 mg/kg) in combination with a broad-spectrum anthelmintic shows moderate efficacy against caprine Trichostrongylus spp, but is highly effective against Haemonchus contortus. In mice with Fasciola hepatica metacercarial cysts, treatment with closantel (10 mg/kg) leads to extensive peeling on the anterior and posterior extremities, as well as the dorsal and ventral surfaces, resulting in significant overall dermal damage 24 hours post-administration. Furthermore, in sheep infected with resistant H. contortus strains, isotope levels following treatment with radiolabeled closantel are significantly lower compared to susceptible worms. |
| In vivo | Compared to normal conditions, Closantel (50 μg/mL) induces vascular tissue to contract with greater amplitude and higher frequency, reaching a peak muscle tension after approximately 15 minutes, with the amplitude exceeding 1.5 times that of the maximum normal contraction. Additionally, Closantel effectively blocks the infection of host cells by A. phagocytophilum or E. chaffeensis and can clear infections after a one-day treatment in a dose-dependent manner. It also inhibits drug-resistant Enterococcus faecium and Staphylococcus aureus, with minimum inhibitory concentrations (MICs) of 1 μg/mL, and Methicillin-resistant Staphylococcus aureus (MRSA) with a MIC of 2 μg/mL. Moreover, Closantel inhibits the autophosphorylation activity of three sensor kinases derived from E. chaffeensis. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 55 mg/mL (82.95 mM), Sonication is recommended. H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | volvulus | salicylanilide | R31520 | R 31520 | Parasite | OvCHT1 | Onchocerca | O. volvulus | Inhibitor | inhibit | halogenated | fromprotozoans | Closantel | chitotriosidase | chitinase | antibacterial |
| Inhibitors Related | Neomycin sulfate | Dehydroacetic acid sodium | Ampicillin sodium | Kojic acid | Methyl anthranilate | Kanamycin sulfate | Urethane | Sulfamethoxazole sodium | Hydroxychloroquine | Doxycycline | Isoeugenol | Dimethyl sulfoxide |
| Related Compound Libraries | Anti-Parasitic Compound Library | Bioactive Compound Library | Approved Drug Library | ReFRAME Related Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Infection Compound Library | Human Metabolite Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $34.00/50mg |
VIP5Y
|
TargetMol Chemicals Inc.
|
2025-05-12 | |
| $34.00/50mg |
VIP3Y
|
TargetMol Chemicals Inc.
|
2025-05-12 | |
| $300.00/25kg |
VIP4Y
|
Asia Chem I and E (Jiangsu) Co Ltd
|
2024-12-30 | |
| $10.00/1KG |
VIP7Y
|
Hebei Chuanghai Biotechnology Co., Ltd
|
2024-11-26 | |
| $0.00/1KG |
VIP3Y
|
Hebei Chuanghai Biotechnology Co., Ltd
|
2024-11-01 | |
| $10.00/1kg |
Ouhuang Engineering Materials (Hubei) Co., Ltd
|
2024-04-23 | ||
| $0.00/1kg |
VIP2Y
|
Shaanxi TNJONE Pharmaceutical Co., Ltd
|
2024-04-07 | |
| $10.00/1kg |
Nantong Guangyuan Chemicl Co,Ltd
|
2023-11-21 | ||
| $30.00/1kg |
VIP5Y
|
Hebei Yanxi Chemical Co., Ltd.
|
2023-11-16 | |
| $0.00/25KG |
VIP5Y
|
Hebei Mujin Biotechnology Co.,Ltd
|
2023-06-27 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
INQUIRY