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Postion:Product Catalog >Deucravacitinib Impurity
Deucravacitinib Impurity
  • Deucravacitinib Impurity
  • Deucravacitinib Impurity
  • Deucravacitinib Impurity
  • Deucravacitinib Impurity
  • Deucravacitinib Impurity

Deucravacitinib Impurity NEW

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Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-07-31

Product Details

Product Name: Deucravacitinib Impurity CAS No.: 1609392-27-9
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/07/31

Deucravacitinib Impurity ;1609392-27-9

Article illustration


Product Information

  • Product Code:D084000

  • English Name:Deucravacitinib

  • English Alias:6-(cyclopropanecarboxamido)-4-((2-methoxy-3-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl)amino)-N-(methyl-d3)pyridazine-3-carboxamide

  • CAS No.:1609392-27-9

  • Molecular Formula:C??H??D?N?O?

  • Molecular Weight:425.46

Advantages

  • High-Purity Guarantee:Confirmed by HPLC (≥99.5%), combined with multiple techniques such as NMR (1H, 13C, including deuterium signal analysis), HRMS, and elemental analysis, providing accurate reference standards for drug research, development, and quality control.

  • Excellent Stability:Stable for 36 months at -20℃ under light-protected, sealed storage; degradation rate <0.2% in common solvents (such as DMSO, acetonitrile - water system) within 6 months, ensuring reliable experimental data.

Applications

  • Drug Development:As a novel tyrosine kinase 2 (TYK2) inhibitor, it is used in the development of drugs for autoimmune diseases such as psoriasis. It regulates the immune response and reduces the release of inflammatory factors by inhibiting the TYK2 signaling pathway.

  • Preclinical Research:In pharmacokinetic studies, its deuterated structure is utilized to explore the metabolic pathways and elimination patterns in vivo, optimizing dosing regimens; in pharmacodynamic studies, it assesses the therapeutic effects on disease models.

  • Quality Control:Used for UPLC-MS/MS detection of Deucravacitinib in active pharmaceutical ingredients and formulations, controlling impurity content to meet ICH Q3A and Q3B standards, ensuring drug quality and safety.

Background Description

Deucravacitinib is an innovative oral small-molecule drug targeting tyrosine kinase 2 (TYK2). Autoimmune diseases such as psoriasis and rheumatoid arthritis are closely related to the abnormal activation of signaling pathways within immune cells. As a key signaling molecule, TYK2 is involved in the signal transduction of cytokines such as interferons and interleukins. Traditional therapeutic drugs have limitations in efficacy and significant side effects. Deucravacitinib specifically binds to the regulatory domain of TYK2, blocking its activation and avoiding widespread inhibition of other kinases, thus enabling more precise and safe immune regulation and bringing new directions for the treatment of autoimmune diseases.

Research Status

  • Clinical Application Progress:Approved for the treatment of psoriasis. Data from multiple Phase III clinical trials show that it significantly improves patients' skin symptoms and quality of life compared with placebo; clinical trials for rheumatoid arthritis, systemic lupus erythematosus, and other diseases are ongoing to explore broader indications.

  • In-Depth Mechanism Research:The binding mode of Deucravacitinib to the TYK2 protein is analyzed by cryo-electron microscopy to clarify the molecular mechanism of its highly selective inhibition; gene editing techniques are used to knock down or overexpress TYK2 to further verify its regulatory effect on downstream signaling pathways.

  • Formulation Optimization:Research on new formulation technologies, such as nanoparticle delivery systems and sustained-release formulations, to improve drug bioavailability and patient compliance; evaluate the release characteristics and stability of different formulations in vitro and in vivo to provide better choices for clinical applications


WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com


NOTE!

We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
This product is intended for laboratory use only!

WhatsAPP: +86 17320513646
E-mail: anna@molcoo.com


NEW IN STOCK!

The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery! 



Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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