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Postion:Product Catalog >HDAC8-IN-3
HDAC8-IN-3
  • HDAC8-IN-3

HDAC8-IN-3 NEW

Price $1520 $1980 $2500
Package 25mg 50mg 100mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-04-30

Product Details

Product Name: HDAC8-IN-3 CAS No.: 2432825-93-7
Supply Ability: 10g Release date: 2025/04/30

Product Introduction

Bioactivity

NameHDAC8-IN-3
DescriptionHDAC8-IN-3 (compound P19) is a highly potent HDAC8 inhibitor with an IC50 value of 9.3 μM, inducing thermal stabilization, cytotoxicity, and apoptosis specifically in leukemic cell lines [1].
In vitroHDAC8-IN-3 (compound P19), at concentrations ranging from 5-200 μM over 48 hours, exhibits cytotoxic effects in leukemic cell lines, with specific activity demonstrated in HEK293T cells. When administered at 50 μM, this compound notably inhibits glucose transporter 1 (GLUT1)-mediated glucose transport by reducing GLUT1 expression, achieving a half-maximal inhibitory concentration (IC 50) of 28.2 μM. Additionally, at a concentration of 79.9 μM over 24 hours, HDAC8-IN-3 can induce apoptotic death in CEM leukemia cells, as evidenced by a significant increase in the percentage of apoptotic cells to 60.97%. Cytotoxicity assays conducted with a fixed concentration of 50 μM for 48 hours on K562, KCL22, and CEM leukemia cell lines reported IC 50 values of 79.9, 85.4, and 43.2 μM, respectively, thereby confirming the compound’s effectiveness in inhibiting cell viability across various leukemia models.
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Company Profile Introduction

TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds. 170+ Compound Libraries, 10000+ Noval Small Molecucles,16000+ Nature Compounds TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.

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