Huperzine A is a natural plant alkaloid extracted from the traditional Chinese medicine Huperzine. It is a potent, reversible and highly selective second-generation acetylcholinesterase inhibitor. It is a yellowish to white crystalline powder with high fat solubility and small molecules. It can penetrate the blood-brain barrier well. After entering the central nervous system, it is distributed more in the frontal lobe, temporal lobe, hippocampus and other brain areas closely related to learning and memory. It has a strong inhibitory effect on acetylcholinesterase (AchE) at low doses, significantly increasing the content of acetylcholine (Ach) in the synaptic cleft in the distribution area, thereby enhancing neuronal excitation conduction, strengthening the excitation effect of the learning and memory brain area, and playing a role in improving cognitive function, enhancing memory retention and promoting memory reproduction. It is currently the most successfully developed drug for the treatment of Alzheimer's disease (senile dementia) in China.

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