Indirubin-3′-oxime NEW
| Price | $89 | $129 | $263 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-06 |
Product Details
| Product Name: Indirubin-3′-oxime | CAS No.: 667463-82-3 |
| Purity: 98.34% | Supply Ability: 10g |
| Release date: 2025/05/06 |
Product Introduction
Bioactivity
| Name | Indirubin-3′-oxime |
| Description | Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. |
| In vitro | clear efficacy of I3M + Tq combinations in LC models mediated by suppressing Akt/mTOR/NFκB signalling. |
| In vivo | indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205.?Furthermore, indirubin-3'-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β).?indirubin-3'-monoxime reduced Aβ25-35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism.?Indirubin-3'-monoxime is a promising drug candidate for Alzheimer's disease. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (198.36 mM), Sonication is recommended. |
| Keywords | phosphorylation | MEF2D | JNK | Inhibitor | inhibit | induced | Indirubin-3′-oxime | Indirubin3′oxime | Indirubin 3′ oxime | indirubin | IDR3O | I3O | GSK-3 | GSK3 | Glycogen synthase kinase-3 | Glycogen synthase kinase 3 | Cyclin dependent kinase | collagen | chondrocytes | CDK | cdk | antiplatelet |
| Inhibitors Related | Ribociclib | Cromolyn sodium | Astragaloside IV | Abemaciclib | CHIR-99021 | 4-Chloro-2'-bromoacetophenone | Palbociclib monohydrochloride | (-)-Bornyl acetate | Anisomycin | CASIN | Dinaciclib | Abemaciclib methanesulfonate |
| Related Compound Libraries | Apoptosis Compound Library | Glycometabolism Compound Library | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Kinase Inhibitor Library | Inhibitor Library | Neuroprotective Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/1kg |
VIP1Y
|
Wuhan Circle Star Chem-medical Technology Co.,Ltd
|
2025-01-14 | |
| $0.00/20MG |
VIP4Y
|
Changsha Staherb Natural Ingredients Co., Ltd.
|
2022-09-01 | |
| $125.00/1g/Bag |
VIP4Y
|
Baoji Guokang Bio-Technology Co., Ltd.
|
2021-06-05 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY