
Isorhamnetin NEW
Price | Get Latest Price | ||
Package | 1G | 5G | 10G |
Min. Order: | 1G |
Supply Ability: | 100G |
Update Time: | 2025-05-23 |
Product Details
Product Name: Isorhamnetin | CAS No.: 480-19-3 |
EC-No.: 207-545-5 | Min. Order: 1G |
Purity: 98% | Supply Ability: 100G |
Release date: 2025/05/23 |
Isorhamnetin is a naturally occurring O-methylated flavonol, a subclass of flavonoids, known for its diverse biological activities. Here's a structured overview:
1. Chemical Structure & Classification
Structure: A methylated derivative of quercetin, with a methoxy (-OCH?) group at the 3'-position of the B-ring.
Molecular formula: C??H??O?.Classification: Flavonoid (flavonol subgroup).
2. Natural Sources
Plants: Found in various medicinal herbs and foods:
Ginkgo biloba (leaves),
Hippophae rhamnoides (sea buckthorn),
Opuntia ficus-indica (prickly pear),
Apples, onions, and berries.
Forms: Often exists as glycosides (e.g., isorhamnetin-3-O-glucoside) in plants.
3. Pharmacological Activities
Antioxidant: Scavenges free radicals and enhances cellular antioxidant defenses.
Anti-inflammatory: Inhibits pro-inflammatory cytokines (e.g., TNF-α, IL-6) and enzymes (e.g., COX-2).
Anticancer: Induces apoptosis and inhibits proliferation in cancer cells (e.g., breast, colon).
Cardioprotective: Reduces oxidative stress and improves endothelial function.
Antidiabetic: Enhances insulin sensitivity and inhibits α-glucosidase.
Neuroprotective: Potential role in mitigating Alzheimer’s and Parkinson’s pathologies.
4. Mechanisms of Action
Modulates signaling pathways: NF-κB, MAPK, PI3K/Akt.
Activates Nrf2, boosting antioxidant enzyme production (e.g., SOD, catalase).
Inhibits cyclooxygenase and lipoxygenase enzymes.
5. Applications
Nutraceuticals: Incorporated into supplements for antioxidant support.
Cosmeceuticals: Used in anti-aging skincare products for UV protection and collagen synthesis.
Drug Development: Investigated for cancer, diabetes, and neurodegenerative disease therapies.
6. Metabolism & Bioavailability
Absorption: Limited oral bioavailability due to low solubility and rapid metabolism.
Metabolism: Undergoes phase II metabolism (glucuronidation, sulfation) in the liver.
Excretion: Primarily via urine and feces.
7. Safety
Generally recognized as safe at dietary levels.
High doses may cause mild gastrointestinal issues; no significant toxicity reported in studies.
8. Recent Research Highlights
Antiviral Potential: Studied against SARS-CoV-2 via inhibition of viral proteases.
Gut Microbiota Interaction: Converted by gut bacteria into bioactive metabolites.
Isorhamnetin’s multifunctional properties make it a promising candidate for therapeutic and preventive health applications, though further clinical trials are needed to validate efficacy in humans. Always consult healthcare professionals before using it therapeutically.
Company Profile Introduction
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- Since: 2006-04-03
- Address: Room 2015, No.2 Building Kaixin Mansion, No.107 Jinqiao Ave, Wuhan, China
+86-13986145403
info@fortunachem.com