MAO A/HSP90-IN-1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: MAO A/HSP90-IN-1 | CAS No.: 2927489-95-8 |
| Supply Ability: 10g | Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | MAO A/HSP90-IN-1 |
| Description | MAO A/HSP90-IN-1 (4-b) is a dual inhibitor of MAO A and HSP90, with IC50 values of 1.77 μM in glioblastoma (GBM) GL26 cells and 0.019 μM against HSP90α. This compound impairs MAO A activity, disrupts HSP90 binding, and downregulates HER2 and phospho-Akt expressions, thus inhibiting GBM growth. Additionally, it reduces PD-L1 expression, thwarting T cell activation and potential tumor immune evasion. MAO A/HSP90-IN-1 (4-b) is valuable for research into brain tumor-related diseases [1]. |
| In vitro | MAO A/HSP90-IN-1 (4-b) inhibits GBM cell proliferation by suppressing MAO A and HSP90 at concentrations of 0.1-3 μM over 24 hours [1]. It showed an IC50 of 0.73 μM and 1.68 μM in different GL26 trials and 0.84 μM in U251R cells [1]. At 0, 0.35, 0.7, and 1.4 μM, it also reduced IFN-γ-induced PD-L1 expression in murine glioma GL26 cells after 24 hours [1]. |
| In vivo | MAO A/HSP90-IN-1 (4-b) (25 mg/kg, intraperitoneal injection, daily) suppresses tumor growth in a murine GBM model [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | MonoamineOxidase | Monoamine Oxidase |
| Inhibitors Related | Norharmane | J-147 | Azure B | Iproniazid Phosphate | Paeonol | Isatin | Methylene Blue | Pargyline hydrochloride | Methylene Blue trihydrate | Phenelzine sulfate | Aminoacetone hydrochloride | Bifemelane hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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