ML-SA5 NEW
| Price | $33 | $76 | $133 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-06 |
Product Details
| Product Name: ML-SA5 | CAS No.: 2418670-70-7 |
| Purity: 100.00% | Supply Ability: 10g |
| Release date: 2025/05/06 |
Product Introduction
Bioactivity
| Name | ML-SA5 |
| Description | ML-SA5 is a MCOLN1 agonist that blocks autophagic flux by disrupting fusion between autophagosomes and lysosomes. |
| In vitro | METHODS: 0.05 or 0.1 μM ML-SA5 was used to treat HeLa cells 1 hour and 4 hours after the application of agonists, and the LC3-II levels in HeLa cells were observed. RESULTS ML-SA5 significantly increased the LC3-II levels. ML-SA5 regulates the LC3-II levels by stimulating the activity of MCOLN1 channels. [1] METHODS: Vero cells stably expressing GFP-Lamp1 were transfected with pStrep-mCherry-CvpE. Twenty hours after transfection, cells were treated with DMSO or ML-SA5 (30 μM) for 4 hours. Then, cells were fixed and nucleic acids were stained with DAPI. RESULTS ML-SA5 treatment completely blocked CvpE-induced cytoplasmic vacuolization. [2] |
| In vivo | METHODS: Patu 8988 t cells were injected into the subcutaneous tissue of nude mice, and ML-SA5 (5 μM) was injected into solid tumors daily. Tumor volume was measured daily, and immunohistochemistry and immunoblot analysis were performed after death of mice. RESULTS Administration of ML-SA5 profoundly promoted the survival of Patu 8988 t xenograft mice and inhibited tumor growth. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (109.17 mM), Sonication is recommended. |
| Keywords | ML-SA5 | MLSA5 | ML SA5 | MCOLN1 | Autophagy |
| Inhibitors Related | Stavudine | Xylitol | Aceglutamide | Sodium 4-phenylbutyrate | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Curcumin | Paeonol | Naringin | Gefitinib |
| Related Compound Libraries | Bioactive Compound Library | Autophagy Compound Library | Bioactive Compounds Library Max |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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