PARP1-IN-10 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: PARP1-IN-10 | CAS No.: 2494001-21-5 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | PARP1-IN-10 |
| Description | PARP1-IN-10 (compound 12c) is a highly potent and non-cytotoxic PARP1 inhibitor with an in vitro IC50 value of 50.62 nM, effectively inducing cell cycle arrest at the G2/M phase and apoptosis, while significantly augmenting the cytotoxic effects of temozolomide (TMZ) [1]. |
| In vitro | PARP1-IN-10 (compound 12c) exhibited no cytotoxicity at 10 μM over 48 hours against NCI-60 human tumor cell lines and showed an IC50 of 3.73 μM in inhibiting the MDA-MB-436 cell line. In 48-hour treatments, PARP1-IN-10 induced dose-dependent G2/M phase arrest at 1 and 3.73 μM and, at 0.5 μM, significantly enhanced temozolomide (TMZ) efficacy in A549 cell lines, reducing TMZ's IC50 from 24.2 μM to 3.64 μM. These findings, through cytotoxicity assays, cell cycle, and apoptosis analysis, underscore PARP1-IN-10’s potential as a specific and synergistic therapeutic agent with existing treatments like TMZ. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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