PFI-2 NEW
| Price | $83 | $131 | $448 |
| Package | 5mg | 10mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-19 |
Product Details
| Product Name: PFI-2 | CAS No.: 1627676-59-8 |
| Purity: 99.38% | Supply Ability: 10g |
| Release date: 2025/05/19 |
Product Introduction
Bioactivity
| Name | PFI-2 |
| Description | PFI-2 is an effective, specific and cell-active lysine methyltransferase SETD7 inhibitor (Ki/IC50: 0.33/2 nM), 1000-fold selectivity over other methyltransferases and other non-epigenetic targets. |
| In vivo | In the cellular environment, through direct interaction with SETD7, PFI-2 affects Yes-associated protein localization in Hippo pathway signaling and the putative phenotype Setd7 gene deletion. The inhibitory activity of (R)-PFI-2 on human SETD7 was 500-fold higher than that of its isomer, (S)-PFI-2. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : 66 mg/mL (132.12 mM), Heating is recommended. DMSO : 100 mg/mL (200.19 mM), Sonication is recommended. |
| Keywords | SETD7 | SET domain containing lysine methyltransferase 7 (SETD7) | renal fibrosis | PFI-2 | macrophage | Inhibitor | inhibit | inflammation | HistoneMethyltransferase | Histone Methyltransferase | chronic kidney disease |
| Inhibitors Related | MAK-683 hydrochloride | ORIC-944 | Tazemetostat | Piribedil | XY1 | UNC 0631 | MAK683 | EPZ015666 | iso-Azalansta | AMI-1 free acid | MS37452 | MRTX-1719 |
| Related Compound Libraries | Membrane Protein-targeted Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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