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Postion:Product Catalog >Biochemical Engineering>Polypeptide>PNC-27
PNC-27
  • PNC-27

PNC-27 NEW

Price $600
Package 1BOX
Min. Order: 1BOX
Supply Ability: 10000
Update Time: 2025-03-22

Product Details

Product Name: PNC-27 CAS No.: 1159861-00-3
Min. Order: 1BOX Purity: 5MG
Supply Ability: 10000 Release date: 2025/03/22

PNC-27 is a synthetic anticancer peptide designed to selectively kill cancer cells by targeting a specific protein found on their membranes. It has generated significant interest in preclinical studies due to its unique mechanism of action and potential selectivity for malignant cells.


?? What is PNC-27?

PNC-27 is a peptide derived from the p53 tumor suppressor protein, specifically from its HDM-2 binding domain (amino acids 12–26), linked to a membrane-residency peptide (MRP) sequence. This design allows PNC-27 to:

  • Target HDM-2, a protein overexpressed on the membranes of many cancer cells.

  • Form pores in the cancer cell membrane, causing rapid necrotic cell death.


?? How It Works

Unlike traditional chemotherapeutic agents:

  • PNC-27 doesn't require the p53 pathway to be functional.

  • It physically binds to HDM-2 on the cancer cell surface, and this interaction helps the peptide insert into the cell membrane and form pores.

  • The pores disrupt membrane integrity, leading to cell lysis and necrosis.

Healthy (non-cancerous) cells, which generally do not express HDM-2 on their membranes, appear to be unaffected in preclinical studies.


?? What Has Research Shown So Far?

In lab-based and animal model studies:

  • PNC-27 has shown cytotoxic effects on various cancer cell lines, including:

    • Pancreatic

    • Melanoma

    • Breast

    • Colon

    • Leukemia (e.g., K562)

  • It has induced tumor regression in mice without affecting healthy tissue.


?? FDA & Safety Concerns

Despite promising lab results, PNC-27 is not FDA-approved for cancer treatment. In fact:

  • The FDA issued a public warning against the use of PNC-27 due to:

    • Lack of proven efficacy in humans

    • Potential contamination risks in some products

    • Adverse effects reported in experimental use (e.g., gastrointestinal hemorrhage)


?? Clinical Use Status

  • No approved human trials have demonstrated its safety or efficacy.

  • It is not available as a legitimate pharmaceutical cancer treatment.

  • Patients are strongly advised not to self-administer PNC-27 or use unregulated sources.


?? Summary

FeatureDetails
TypeSynthetic anticancer peptide
MechanismMembrane pore formation via HDM-2 binding
TargetsCancer cells with surface HDM-2
StatusNot FDA-approved, preclinical research stage
RisksUnknown safety in humans, potential serious side effects

If you're interested, I can also summarize the latest research publications on PNC-27 or show comparisons with other experimental cancer peptides. Just let me know!


Company Profile Introduction

Shanghai Longyu Biotech Co.,Ltd. is located in Shanghai, China . We are mainly engaged in pharmaceutical intermediates, peptides,plant extracts, high-tech chemical products and flavors.We have our own R&D center, quality inspection center and manufacturing base.We have professional R&D and scientific management personnel to provide high quality and customized products according to customers' requirements. Customers' satisfactory, Quality control and Safe delivery of our products are the most important concerns and ,in order to fulfil that we have a professional sales team and rich experience in export transportation.Customer satisfaction is the eternal pursuit of the company! We sincerely hope to establish long-term cooperation and common development with our customers.

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  • Since: 2001-09-02
  • Address: Jinshan District ,Shanghai
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