SHP2-IN-13 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-29 |
Product Details
| Product Name: SHP2-IN-13 | CAS No.: 2951854-02-5 |
| Supply Ability: 10g | Release date: 2025/04/29 |
Product Introduction
Bioactivity
| Name | SHP2-IN-13 |
| Description | SHP2-IN-13 is an orally active, highly selective allosteric inhibitor targeting the SHP2 "tunnel site," exhibiting an IC50 of 83.0 nM. It holds potential for research into cancers with RTK oncogenic drivers and diseases associated with SHP2. |
| In vitro | SHP2-IN-13 (compound 129) effectively inhibits the pERK signaling pathway in a dose-dependent manner, with IC50 values of 0.59 μM in NSCLC cells and 0.63 ± 0.32 μM in NCI-H1975-OR cells [1]. At concentrations from 0 to 30 μM over 24 hours, it suppresses pERK levels and RTK-driven proliferation in NCI-H1975 cells and inhibits pERK levels in RTK-resistant NSCLC cells [1]. |
| In vivo | In pharmacokinetic studies, SHP2-IN-13 (compound 129) (IV/PO; 5mg/kg) demonstrated high clearance, substantial volume of distribution (13.9 L/kg), and a moderate half-life (T 1/2 = 5.31 h), with oral bioavailability (F= 55.07±7.93%) exceeding that of SHP099 (F= 46%), making it suitable for further in vivo antitumor pharmacodynamic evaluation [1]. SHP2-IN-13 (oral gavage; 20 mg/kg; daily) exhibited potent anti-leukemic efficacy, which significantly reduced leukemic burden, and nearly eradicated CD45+ leukemic cells from human blood and spleen samples [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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