Triglycidyl isocyanurate NEW
| Price | $29 |
| Package | 5g |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: Triglycidyl isocyanurate | CAS No.: 2451-62-9 |
| Purity: 99.01% | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | Triglycidyl isocyanurate |
| Description | Triglycidyl isocyanurate (Teroxirone) is a triazene triepoxide with antineoplastic and antiangiogenic activity. It inhibits growth of human non-small cell lung cancer cells by activating p53. Triglycidyl isocyanurate alkylates and cross-links DNA, thereby inhibiting DNA replication. It induces cell apoptosis and can be used for cancer research[1][2]. Triglycidyl isocyanurate is also used in various polyester powder coatings in the metal finishing industry. |
| Cell Research | Triglycidyl isocyanurate (0-30 μM; 48?hours) Inhibited tumor cells(A549, H460 and H1299 cells)growth in soft agar. Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibited akt1/2/3 expression and p-aktser473/474/472 expression of A549, H460 and H1299 tumorspheres. |
| Animal Research | Triglycidyl isocyanurate (Female nu/nu mice with Huh7 cells subcutaneously injected into the dorsal area; 1.8 and 3.6 mg/kg; every 2–3 days for total seven times; 30 days)Inhibited the growth of xenograft tumors[2]. |
| In vitro | Triglycidyl isocyanurate (0-30 μM; 48?hours) inhibits expression of akt1/2/3 and phosphorylated Aktser473/474/472 of A549, H460 and H1299 tumorspheres, however, the cleavage of PARP and procaspase-3 plus the emergent active caspase-3 fragment are only visible in H460 and A549 tumorspheres[1]. Triglycidyl isocyanurate (0-30 μM; 48?hours) reduces the growth of spheroids of human non-small-cell-lung cancer cells in culture, it leads to a gradual reduction in size for tumorspheres of A549, H460 and H1299 cells[1]. |
| In vivo | Triglycidyl isocyanurate (subcutaneous injection; 1.8 and 3.6 mg/kg; every 2-3 days for a total of seven doses over 30 days) suppresses xenograft tumor growth without affecting weight in nude mice[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (168.2 mM), Sonication is recommended. |
| Keywords | tumor | Triglycidyl isocyanurate | p53-MDM2 | p53 | NSCLC | MDM-2/p53 | liver cancer | Inhibitor | inhibit | HepG2 | hepatocellular | Hep3B | HCC | DNA synthesis | carcinoma | Apoptosis | anticancer agent |
| Inhibitors Related | Stavudine | 5-Fluorouracil | Acetylcysteine | Myricetin | Sodium 4-phenylbutyrate | L-Ascorbic acid | Dextran sulfate sodium salt (MW 4500-5500) | L-Glutamic acid | Metronidazole | Tributyrin | L-Ascorbic acid sodium salt | Salicylic acid |
| Related Compound Libraries | Ferroptosis Compound Library | Apoptosis Compound Library | Anti-Colorectal Cancer Compound Library | Ubiquitination Compound Library | Pyroptosis Compound Library | NO PAINS Compound Library | PPI Inhibitor Library | Anti-Aging Compound Library | Covalent Inhibitor Library | Anti-Cancer Compound Library | Human Metabolite Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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