TRK-IN-24 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: TRK-IN-24 | CAS No.: 2937544-01-7 |
| Supply Ability: 10g | Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | TRK-IN-24 |
| Description | TRK-IN-24 (compound 10g) is a selective inhibitor of Trk receptors, effectively targeting TRKA, TRKC, and mutant forms TRKA G595R, TRKA G667C, and TRKA F589L, with corresponding IC50 values of 5.21, 4.51, 6.77, 1.42, and 6.13 nM. It demonstrates antitumor activity in BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C xenograft models and inhibits the proliferation of Ba/F3 cells expressing single mutants SF, GK, and xDFG, with an IC50 range of 1.43-47.56 nM [1]. |
| In vitro | TRK-IN-24 (Compound 10g) at concentrations ranging from 3.7 to 300 nM inhibits the phosphorylation of AKT, TRKA, PLCγ1, and ERK in Ba/F3 cells [1]. |
| In vivo | TRK-IN-24 (compound 10g) administered at 50 mg/kg for 10-14 days resulted in 72% and 78% tumor regression in murine xenograft models of BaF3-CD74-NTRK1 G595R and BaF3-CD74-NTRK1 G667C, respectively [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | Trkreceptor | Trk receptor |
| Inhibitors Related | Entrectinib | Larotrectinib sulfate | N-Acetyl-5-hydroxytryptamine | Selitrectinib | Sitravatinib | SP600125 | Amitriptyline hydrochloride | 7,8-Dihydroxyflavone | Tepotinib | Diosmetin | GW 441756 | ALE-0540 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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