YM-46303 NEW
| Price | $700 | $1800 |
| Package | 1mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-17 |
Product Details
| Product Name: YM-46303 | CAS No.: 171722-81-9 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/07/17 |
Product Introduction
Bioactivity
| Name | YM-46303 |
| Description | YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats. |
| In vivo | YM-46303, when compared to oxybutynin, exhibits approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, along with about a 5-fold greater selectivity for urinary bladder contraction over salivary secretion in rats. Evaluation of antimuscarinic effects on bradycardia and pressor responses in pithed rats, as well as on tremor in mice, reveals that YM-46303 could be valuable for treating urinary urge incontinence. It functions as a bladder-selective M3 antagonist with potent activities and fewer side effects[1]. In vivo, YM-46303 demonstrates selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. Additionally, it shows potent activity in a guinea pig model of methacholine-induced bronchospasm upon intravenous administration[1]. |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Keywords | YM-46303 | YM46303 | YM 46303 | mAChR | M3 mAChR |
| Inhibitors Related | Adiphenine hydrochloride | Nanofin | Forskolin | Pilocarpine Hydrochloride | (+)-Sparteine | Clozapine N-Oxide | Pilocarpine nitrate | Ribavirin | D-Menthol | Amitriptyline hydrochloride | Choline chloride | Propoxur |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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