(Z)-Lanoconazole NEW
| Price | $49 |
| Package | 2mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: (Z)-Lanoconazole | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | (Z)-Lanoconazole |
| Description | (Z)-Lanoconazole is the Z configuration of Lanoconazole, used for investigating dermatophytosis and onychomycosis. It inhibits sterol 14-alpha demethylase, disrupting fungal membrane ergosterol biosynthesis. Lanoconazole is a potent, orally active imidazole antifungal agent with a broad spectrum of activity against fungi both in vitro and in vivo [1] [2]. |
| In vivo | Lanoconazole effectively mitigates TPA-induced irritant dermatitis through a dose-dependent mechanism (treatment applied to the ear; concentrations between 0.3%-3%; over 6 days), by reducing the production of neutrophil chemotactic factors, including keratinocyte-derived chemokine and macrophage inflammatory protein-2, and by inhibiting neutrophil migration to the site of inflammation [2]. Furthermore, when administered orally at doses of 3, 10, or 30 mg/kg once daily for three weeks, lanoconazole significantly hampers the growth of C. neoformans in comparison to a saline control in healthy mice. It also notably decreases the proliferation of C. neoformans in the lungs and brains of MAIDS mice, demonstrating its potent antifungal efficacy [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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