REVIEW Beta-Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands. It plays a key role in insect development, cell proliferaton, growth and apoptosis by controlling gene expression involved in moulting and metamorphosis. BetaEcdysone is an Ecdysone receptor (EcR) agonist. It acts through a heterodimeric receptor comprising the ecdysone receptor (EcR) and the ultraspiracle proteins.
REFERENCES
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Ashburner, Michael; Richards, Geoff. The role of ecdysone in the control of gene activity in the polytene chromosomes of Drosophila. Symposium of the Royal Entomological Society of London. (1976) 8(Insect Dev.): 203-25.
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Swevers Luc; Iatrou Kostas. The ecdysone regulatory cascade and ovarian development in lepidopteran insects: insights from the silkmoth paradigm Insect. Biochemistry and Molecular Biology. (2003) 33(12): 1285-97.
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Fallon, Ann M.; Gerenday, Anna. Ecdysone and the cell cycle: Investigations in a mosquito cell line. Journal of Insect Physiology. (2010) 56(10): 1396-1401.
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Mori, Hiromu; Shibata, Kenyu Synthesis of ecdysterone Chemical & Pharmaceutical Bulletin (1969), 17(9), 1970-3
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