REVIEW Prednisone is a glucocorticoid receptor agonist. It is first metabolized in the liver to its active form, prednisolone. Prednisolone crosses cell membranes and binds with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.
REFERENCES
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Mazurek S, Szostak R (2012). Quantitative determination of prednisone in tablets by infrared attenuated total reflection and Raman spectroscopy. J AOAC Int. 95(3):744-50. PMID 22816265.
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Nasseri E, Belisle A, Funaro D (2012). Rosai-Dorfman disease treated with methotrexate and low-dose prednisone: case report and review of the literature. J Cutan Med Surg. 16(4):281-5. PMID 22784522.
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