Chaetocin
Chaetocin (CAS number 28097-03-2) is a naturally occurring dithio-diketopiperazine metabolite derived from Chaetomium species, characterized as an inhibitor targeting lysine-specific histone methyltransferases. It acts primarily by inhibiting SUV39H1, a methyltransferase responsible for methylating lysine 9 on histone H3 (H3K9), with an IC50 of approximately 0.8 μM. Functionally, chaetocin decreases methylation at both H3K9 and H3K27 residues, induces apoptosis and cellular differentiation in various cancer cell lines such as HL-60 and KG-1a, and exhibits potent antimyeloma activity by inducing oxidative stress through inhibition of thioredoxin reductase. Due to these properties, chaetocin has relevance in epigenetic research and cancer therapeutics studies, notably demonstrated in animal models of multiple myeloma.
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 696.84 |
| Cas No. | 28097-03-2 |
| Formula | C30H28N6O6S4 |
| Solubility | ≥50.4 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O |
| Chemical Name | (3S,3'S,6R,6'R,14R,14'R,16S,16'S)-3,3'-bis(hydroxymethyl)-2,2'-dimethyl-2,2',3,3',6,6',7,7'-octahydro-1H,1'H-[14,14'-bi(3,11a-epidithiopyrazino[1',2':1,5]pyrrolo[2,3-b]indole)]-1,1',4,4'(15H,15'H)-tetraone |
| SDF | Download SDF |
| Canonical SMILES | O=C1[C@](CO)(SS2)N(C)C([C@]32N1[C@]4([H])[C@](C(C=CC=C5)=C5N4)([C@@]6(C(C=CC=C7)=C7N8)[C@@]8([H])N(C([C@](CO)(SS9)N%10C)=O)[C@]9(C6)C%10=O)C3)=O |
| Shipping Condition | Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice. |
| General tips | We do not recommend long-term storage for the solution, please use it up soon. |
Quality Control & MSDS
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Purity = 98.00%
- COA (Certificate Of Analysis)
- MSDS (Material Safety Data Sheet)
- Datasheet
Chemical structure
