JNK Inhibitor VIII

別名: TCS?JNK?6o 中文名稱：JNK抑制劑8

目錄號：S7794 Purity: 99.77%

JNK Inhibitor VIII (TCS JNK 6o) 是一種 c-Jun N-terminal kinases 的抑制劑，對JNK-1和JNK-2的IC50值分別為45 nM和160 nM。JNK Inhibitor VIII (TCS JNK 6o) 可抑制JNK-1、JNK-2和JNK-3，對應(yīng)的Ki值分別為2 nM、4 nM和52 nM。

JNK Inhibitor VIII Chemical Structure

CAS: 894804-07-0

規(guī)格	價格	庫存
2mg	997	現(xiàn)貨
5mg	1970	現(xiàn)貨
25mg	5487.3	現(xiàn)貨
100mg	12039.3	現(xiàn)貨
更大包裝有超大折扣
400-668-6834 info@selleck.cn

產(chǎn)品質(zhì)控

批次： S779401 DMSO]71 mg/mL]false]Water]Insoluble]false]Ethanol]Insoluble]false 純度： 99.77%

99.77

JNK Inhibitor VIII相關(guān)產(chǎn)品

相關(guān)靶點	JNK1 JNK2 JNK3	點擊展開
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相關(guān)化合物庫	激酶抑制劑庫 MAPK抑制劑庫細胞周期化合物庫 TGF-beta/Smad信號通路庫抗阿爾茨海默病化合物庫	點擊展開

細胞實驗數(shù)據(jù)示例

細胞系	實驗類型	活性描述	文獻信息
NB7	Growth inhibition assay	Inhibition of human NB7 cell growth in a cell viability assay, IC50=2.27473μM	SANGER
LB2241-RCC	Growth inhibition assay	Inhibition of human LB2241-RCC cell growth in a cell viability assay, IC50=6.57739μM	SANGER
NCI-H1299	Growth inhibition assay	Inhibition of human NCI-H1299 cell growth in a cell viability assay, IC50=13.2019μM	SANGER
BV-173	Growth inhibition assay	Inhibition of human BV-173 cell growth in a cell viability assay, IC50=14.0505μM	SANGER
HPAF-II	Growth inhibition assay	Inhibition of human HPAF-II cell growth in a cell viability assay, IC50=14.5873μM	SANGER
RS4-11	Growth inhibition assay	Inhibition of human RS4-11 cell growth in a cell viability assay, IC50=16.6795μM	SANGER
EW-1	Growth inhibition assay	Inhibition of human EW-1 cell growth in a cell viability assay, IC50=17.1883μM	SANGER
NCI-H1581	Growth inhibition assay	Inhibition of human NCI-H1581 cell growth in a cell viability assay, IC50=17.2588μM	SANGER
SK-PN-DW	Growth inhibition assay	Inhibition of human SK-PN-DW cell growth in a cell viability assay, IC50=17.9485μM	SANGER
KP-4	Growth inhibition assay	Inhibition of human KP-4 cell growth in a cell viability assay, IC50=19.1087μM	SANGER
DU-145	Growth inhibition assay	Inhibition of human DU-145 cell growth in a cell viability assay, IC50=19.8748μM	SANGER
ACHN	Growth inhibition assay	Inhibition of human ACHN cell growth in a cell viability assay, IC50=20.6213μM	SANGER
A172	Growth inhibition assay	Inhibition of human A172 cell growth in a cell viability assay, IC50=21.263μM	SANGER
HuO-3N1	Growth inhibition assay	Inhibition of human HuO-3N1 cell growth in a cell viability assay, IC50=21.4318μM	SANGER
QIMR-WIL	Growth inhibition assay	Inhibition of human QIMR-WIL cell growth in a cell viability assay, IC50=22.3274μM	SANGER
NCI-H1650	Growth inhibition assay	Inhibition of human NCI-H1650 cell growth in a cell viability assay, IC50=22.7873μM	SANGER
SW1088	Growth inhibition assay	Inhibition of human SW1088 cell growth in a cell viability assay, IC50=23.1641μM	SANGER
Mewo	Growth inhibition assay	Inhibition of human Mewo cell growth in a cell viability assay, IC50=23.3997μM	SANGER
NCI-H1355	Growth inhibition assay	Inhibition of human NCI-H1355 cell growth in a cell viability assay, IC50=24.6365μM	SANGER
SK-LU-1	Growth inhibition assay	Inhibition of human SK-LU-1 cell growth in a cell viability assay, IC50=27.058μM	SANGER
KYSE-70	Growth inhibition assay	Inhibition of human KYSE-70 cell growth in a cell viability assay, IC50=27.125μM	SANGER
KP-N-YS	Growth inhibition assay	Inhibition of human KP-N-YS cell growth in a cell viability assay, IC50=27.5706μM	SANGER
HTC-C3	Growth inhibition assay	Inhibition of human HTC-C3 cell growth in a cell viability assay, IC50=27.7345μM	SANGER
NB17	Growth inhibition assay	Inhibition of human NB17 cell growth in a cell viability assay, IC50=27.9113μM	SANGER
GOTO	Growth inhibition assay	Inhibition of human GOTO cell growth in a cell viability assay, IC50=27.9415μM	SANGER
BEN	Growth inhibition assay	Inhibition of human BEN cell growth in a cell viability assay, IC50=29.865μM	SANGER
HMV-II	Growth inhibition assay	Inhibition of human HMV-II cell growth in a cell viability assay, IC50=30.1553μM	SANGER
SF295	Growth inhibition assay	Inhibition of human SF295 cell growth in a cell viability assay, IC50=32.156μM	SANGER
MPP-89	Growth inhibition assay	Inhibition of human MPP-89 cell growth in a cell viability assay, IC50=33.5199μM	SANGER
LCLC-103H	Growth inhibition assay	Inhibition of human LCLC-103H cell growth in a cell viability assay, IC50=34.2223μM	SANGER
MN-60	Growth inhibition assay	Inhibition of human MN-60 cell growth in a cell viability assay, IC50=36.0139μM	SANGER
BB65-RCC	Growth inhibition assay	Inhibition of human BB65-RCC cell growth in a cell viability assay, IC50=36.1528μM	SANGER
BHY	Growth inhibition assay	Inhibition of human BHY cell growth in a cell viability assay, IC50=36.9645μM	SANGER
SK-MEL-3	Growth inhibition assay	Inhibition of human SK-MEL-3 cell growth in a cell viability assay, IC50=37.7324μM	SANGER
NY	Growth inhibition assay	Inhibition of human NY cell growth in a cell viability assay, IC50=37.7592μM	SANGER
CAL-72	Growth inhibition assay	Inhibition of human CAL-72 cell growth in a cell viability assay, IC50=37.9289μM	SANGER
ES3	Growth inhibition assay	Inhibition of human ES3 cell growth in a cell viability assay, IC50=38.1949μM	SANGER
NBsusSR	Growth inhibition assay	Inhibition of human NBsusSR cell growth in a cell viability assay, IC50=39.3132μM	SANGER
NB10	Growth inhibition assay	Inhibition of human NB10 cell growth in a cell viability assay, IC50=40.1731μM	SANGER
ChaGo-K-1	Growth inhibition assay	Inhibition of human ChaGo-K-1 cell growth in a cell viability assay, IC50=41.1576μM	SANGER
KYSE-450	Growth inhibition assay	Inhibition of human KYSE-450 cell growth in a cell viability assay, IC50=41.4514μM	SANGER
SK-MEL-1	Growth inhibition assay	Inhibition of human SK-MEL-1 cell growth in a cell viability assay, IC50=41.9927μM	SANGER
PC-3	Growth inhibition assay	Inhibition of human PC-3 cell growth in a cell viability assay, IC50=42.2752μM	SANGER
KARPAS-299	Growth inhibition assay	Inhibition of human KARPAS-299 cell growth in a cell viability assay, IC50=44.5948μM	SANGER
DBTRG-05MG	Growth inhibition assay	Inhibition of human DBTRG-05MG cell growth in a cell viability assay, IC50=44.6546μM	SANGER
HCC1806	Growth inhibition assay	Inhibition of human HCC1806 cell growth in a cell viability assay, IC50=45.2169μM	SANGER
NCI-H2009	Growth inhibition assay	Inhibition of human NCI-H2009 cell growth in a cell viability assay, IC50=45.2843μM	SANGER
HCC2157	Growth inhibition assay	Inhibition of human HCC2157 cell growth in a cell viability assay, IC50=45.7976μM	SANGER
EM-2	Growth inhibition assay	Inhibition of human EM-2 cell growth in a cell viability assay, IC50=47.4011μM	SANGER
DOK	Growth inhibition assay	Inhibition of human DOK cell growth in a cell viability assay, IC50=48.3877μM	SANGER
HepG2	Function assay	Inhibition of cJun phosphorylation in HepG2 cell line, Ki=0.004μM	16759099
HepG2	Function assay	Inhibition of cJun phosphorylation in HepG2 cell line, EC50=0.92μM	16759099
點擊查看更多細胞系數(shù)據(jù)

生物活性

產(chǎn)品描述

靶點

JNK1 ^[1] (Cell-free assay)	JNK2 ^[1] (Cell-free assay)	JNK1 ^[1] (Cell-free assay)	JNK3 ^[1] (Cell-free assay)	JNK2 ^[1] (Cell-free assay)
2 nM(Ki)	4 nM(Ki)	45 nM	52 nM(Ki)	160 nM

參考文獻
[1] Bruce G Szczepankiewicz, et al. J Med Chem. 2006 Jun 15;49(12):3563-80.

參考文獻

[1] Bruce G Szczepankiewicz, et al. J Med Chem. 2006 Jun 15;49(12):3563-80.

化學(xué)信息&溶解度

分子量	356.38	分子式	C₁₈H₂₀N₄O₄
CAS號	894804-07-0	SDF	--
Smiles	CCOC1=C(C(=CC(=N1)NC(=O)CC2=C(C=CC(=C2)OC)OC)N)C#N
儲存條件(自收到貨起)	3年 -20°C 粉狀	儲備液保存和期限建議分裝儲備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲存條件(自收到貨起)	3年 -20°C 粉狀	儲備液保存和期限建議分裝儲備液，避免反復(fù)凍融！	1個月-20°C溶于溶劑

體外溶解度
批次：

DMSO : 71 mg/mL ( (199.22 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Water : Insoluble

Ethanol : Insoluble

摩爾濃度計算器

體內(nèi)溶解配方批次：現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑				動物體內(nèi)配方計算器
均勻懸濁液	CMC-NA	≥5mg/ml	以 1 mL 工作液為例，取 5 mg該產(chǎn)品加到 1 ml CMC-NA 溶液中，混合均勻，即可得工作液濃度為 5 mg/ml的均勻懸濁液。
澄清溶液	5%DMSO 1 40%PEG300 2 5%Tween80 3 50%ddH2O 該配方已經(jīng)過Selleck實驗室實測。如果上述溶解方案不能滿足您的需求，可聯(lián)系Selleck銷售提供定制化測試。	3.550mg/ml (9.96mM)	以 1 mL 工作液為例,取50μL71mg/ml的澄清DMSO儲備液加到400μLPEG300中,混合均勻使其澄清;向上述體系中加入50μLTween80,混合均勻使其澄清;然后繼續(xù)加入500μLddH2O定容至1mL。工作液請現(xiàn)配現(xiàn)用!
澄清溶液	5% DMSO 1 95% Corn oil 該配方已經(jīng)過Selleck實驗室實測。如果上述溶解方案不能滿足您的需求，可聯(lián)系Selleck銷售提供定制化測試。	1.700mg/ml (4.77mM)	以1 mL工作液為例，取50μL 34mg/ml的澄清DMSO儲備液加到950μL玉米油中，混合均勻。工作液請現(xiàn)配現(xiàn)用！

實驗計算

摩爾濃度計算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計算器分子量計算器

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

給藥劑量 mg/kg 動物平均體重 g 每只動物給藥體積 μL 動物數(shù)量只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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C1=C0/X	C1:	LOG(C1):
C2=C1/X	C2:	LOG(C2):
C3=C2/X	C3:	LOG(C3):
C4=C3/X	C4:	LOG(C4):
C5=C4/X	C5:	LOG(C5):
C6=C5/X	C6:	LOG(C6):
C7=C6/X	C7:	LOG(C7):
C8=C7/X	C8:	LOG(C8):

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