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  2. GPCR/G Protein
  3. Platelet-activating Factor Receptor (PAFR)
  4. 48740 RP

48740 RP ((Rac)-RP-55778) 是一種血小板激活因子 (PAF) 拮抗劑。

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48740 RP Chemical Structure

48740 RP Chemical Structure

CAS No. : 93363-11-2

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥7200
1 - 2 周
5 mg   詢價(jià)  
10 mg   詢價(jià)  

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  • 生物活性

  • 實(shí)驗(yàn)參考方法

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

48740 RP ((Rac)-RP-55778) is a platelet-activating factor (PAF) antagonist.

IC50 & Target

PAF[1]
體內(nèi)研究
(In Vivo)

48740 RP ((Rac)-RP-55778) is a platelet-activating factor (PAF) antagonist. In animals treated with 48740 RP only, the number of platelets is increased at a time corresponding to 2 and 4 h after the exposure to lipopolysaccharide (LPS) and the number of eosinophils is also slightly increased. Treatment with 48740 RP in combination with the LPS exposure does not influence the increase in neutrophils seen 2 and 4 h after exposure. At 24 h the increase in the number of neutrophils is about half that in control animals. No effects are found on the LPS-induced increase in number of platelets. In animals pretreated with 48740 RP, there is a significant reduction in capillary permeability[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

245.30

Formula

C12H11N3OS
CAS 號(hào)
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)
Animal Administration
[1]

Guinea pigs of both sexes weighing 300 to 500 g are used for the determination of free lung cell responses and histopathologic examination. Male hamsters, weighing 100 g, are used for capillary permeability determinations. Guinea pigs are pretreated with an intraperitoneal injection of 48740 RP at 20 mg/kg in saline 1 h before exposure to lipopolysaccharide (LPS) and immediately thereafter. Groups of hamsters (n=6) are treated immediately before aerosol exposure, immediately after, and 3 h afterwards[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
參考文獻(xiàn)

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  • 稀釋計(jì)算器

The molarity calculator equation

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質(zhì)量   濃度   體積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
48740 RP
目錄號(hào)：
HY-100153
需求量：