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  2. Protein Tyrosine Kinase/RTK
  3. Src
  4. LCB 03-0110

LCB 03-0110 是一種噻吩并吡啶衍生物，是一種有效的泛盤狀蛋白結(jié)構(gòu)域受體/c-Src 家族酪氨酸激酶抑制劑。LCB 03-0110 通過抑制成纖維細(xì)胞和巨噬細(xì)胞活化來抑制疤痕形成。

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LCB 03-0110 Chemical Structure

LCB 03-0110 Chemical Structure

CAS No. : 1228102-01-9

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥2210
1 - 2 周
5 mg   詢價  
10 mg   詢價  

* Please select Quantity before adding items.

Customer Review

Other Forms of LCB 03-0110:

查看 Src 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

LCB 03-0110, a thienopyridine derivative, is a potent pan-discoidin domain receptor/c-Src family tyrosine kinase inhibitor. LCB 03-0110 suppresses scar formation by inhibiting fibroblast and macrophage activation[1].

細(xì)胞效力
(Cellular Effect)
Cell Line Type Value Description References
HEK293 IC50
164 nM
Compound: 13, LCB-03-0110
Inhibition of human DDR1b expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot method
Inhibition of human DDR1b expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot method
[PMID: 25569119]
HEK293 IC50
164 nM
Compound: 6, LCB 03-0110
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR1 expressed in HEK293 cells by Western blotting analysis
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR1 expressed in HEK293 cells by Western blotting analysis
[PMID: 23521020]
HEK293 IC50
171 nM
Compound: 13, LCB-03-0110
Inhibition of human DDR2 expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot method
Inhibition of human DDR2 expressed in HEK293 cells assessed as reduction in collagen-1-induced receptor auto-phosphorylation by Western blot method
[PMID: 25569119]
HEK293 IC50
171 nM
Compound: 6, LCB 03-0110
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR2 expressed in HEK293 cells by Western blotting analysis
Inhibition of type 1 collagen-induced autophosphorylation of human recombinant DDR2 expressed in HEK293 cells by Western blotting analysis
[PMID: 23521020]
體外研究
(In Vitro)

LCB 03-0110 抑制轉(zhuǎn)化生長因子 β1 和 I 型膠原誘導(dǎo)的原代真皮成纖維細(xì)胞的增殖和遷移[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

LCB 03-0110 可抑制愈合傷口中肌成纖維細(xì)胞和巨噬細(xì)胞的積累，并減少兔耳傷口閉合后肥厚性疤痕的形成[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

417.52

Formula

C24H23N3O2S
CAS 號
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻

LCB 03-0110 相關(guān)分類

  • 摩爾計算器

  • 稀釋計算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產(chǎn)品名稱：
LCB 03-0110
目錄號：
HY-110367A
需求量：