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  3. Glycerophospholipids, cephalins

Glycerophospholipids, cephalins 是一類磷脂化合物,是神經(jīng)膜的重要組成成分。Glycerophospholipids, cephalins 是磷脂酶 (如 PLA2、PLC、PLD) 的水解底物,完全水解后分別生成 1 mol 甘油、磷酸、乙醇胺和 2 mol 脂肪酸。Glycerophospholipids, cephalins 可維持膜結(jié)構(gòu)、流動(dòng)性及離子通透性,并作為花生四烯酸和二酰甘油等第二信使的前體。Glycerophospholipids, cephalins 可調(diào)控信號(hào)轉(zhuǎn)導(dǎo)、細(xì)胞凋亡和膜運(yùn)輸,應(yīng)用于神經(jīng)退行性疾病 (如阿爾茨海默病) 的研究。

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Glycerophospholipids, cephalins Chemical Structure

Glycerophospholipids, cephalins Chemical Structure

CAS No. : 39382-08-6

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Glycerophospholipids and cephalins are a class of phospholipid compounds and important components of neural membranes. Glycerophospholipids and cephalins are hydrolysis substrates of phospholipase (such as PLA2, PLC, and PLD). After complete hydrolysis, they produce 1 mol of glycerol, phosphate, ethanolamine, and 2 mol of fatty acids, respectively. Glycerophospholipids and cephalins can maintain membrane structure, fluidity, and ion permeability, and serve as precursors of second messengers such as arachidonic acid and diacylglycerol. Glycerophospholipids and cephalins can regulate signal transduction, cell apoptosis, and membrane transport, and are used in the study of neurodegenerative diseases (such as Alzheimer's disease)[1][2].

體外研究
(In Vitro)

Glycerophospholipids, cephalins (50 μM;24 h) 通過激活磷脂酶 PLA2 并釋放花生四烯酸,增加大鼠皮質(zhì)神經(jīng)元的凋亡率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: Rat hippocampal neurons
Concentration: 20 μM
Incubation Time: 12 h
Result: Increased phosphorylation of PKC and ERK1/2, indicating activation of the PLC/DAG signaling pathway.
體內(nèi)研究
(In Vivo)

Glycerophospholipids, cephalins (3 個(gè)月 DHA 飲食;飲食干預(yù);每日;3 個(gè)月) 在雌性 APP/PS1 轉(zhuǎn)基因小鼠在顯著減少皮質(zhì)和海馬區(qū)淀粉樣斑塊負(fù)荷,并增加海馬區(qū) drebrin 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tg2576 mice (male, weight 18-22g, 6 months old) with Alzheimer’s disease model[1]
Dosage: 100 mg/kg Arachidonic acid (Glycerophospholipids, cephalins metabolism)
Administration: Intraperitoneal injection, once daily, 4 weeks
Result: Induced significant increase in brain F?-isoprostane levels and promoted Aβ1-42 aggregation, leading to cognitive impairment.
CAS 號(hào)
性狀

固體

顏色

Off-white to light yellow

運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.

儲(chǔ)存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細(xì)胞實(shí)驗(yàn): 

THF 中的溶解度 : ≥ 100 mg/mL

H2O 中的溶解度 : 2 mg/mL (超聲助溶 (<60°C))

* "≥" means soluble, but saturation unknown.

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量
=
濃度
×
體積
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start)

C1

×
體積 (start)

V1

=
濃度 (final)

C2

×
體積 (final)

V2

動(dòng)物溶解方案計(jì)算器
請(qǐng)輸入動(dòng)物實(shí)驗(yàn)的基本信息:

給藥劑量

mg/kg

動(dòng)物的平均體重

g

每只動(dòng)物的給藥體積

μL

動(dòng)物數(shù)量

由于實(shí)驗(yàn)過程有損耗,建議您多配一只動(dòng)物的量
計(jì)算結(jié)果
工作液所需濃度 : mg/mL
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純度 & 產(chǎn)品資料

純度: 88.59%

參考文獻(xiàn)

Glycerophospholipids, cephalins 相關(guān)分類

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Glycerophospholipids, cephalins
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