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  2. GPCR/G Protein Neuronal Signaling
  3. Neuropeptide Y Receptor
  4. M40 TFA

M40 TFA 是 M40 的 TFA 鹽形式。M40 TFA 依據(jù)甘丙肽受體 (galanin receptor) 在大腦，下丘腦，海馬體，杏仁核和胰腺中的不同亞型，發(fā)揮拮抗或激動(dòng)作用。

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Custom Peptide Synthesis

M40 TFA Chemical Structure

M40 TFA Chemical Structure

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥3250
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Other Forms of M40 TFA:

  • M40 詢(xún)價(jià)

查看 Neuropeptide Y Receptor 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

M40 TFA is the TFA salt form of M40. M40 TFA is an antagonist or a weak agonist for galanin receptor depending on different subtypes of galanin receptors in the brain, hypothalamus, hippocampus, amygdala and pancreas[1][2][3].

體內(nèi)研究
(In Vivo)

M40 TFA (0.1-1 nmol，腦室內(nèi)注射，單劑量) 根據(jù)對(duì) N 端甘丙肽受體的識(shí)別，選擇性阻斷 Sprague-Dawley 大鼠模型中甘丙肽-(1-15) 誘導(dǎo)的中樞心血管反應(yīng) [1]。
M40 TFA (2-8 nmol，腦室或海馬體內(nèi)注射，單劑量) 在 SD 大鼠模型中表現(xiàn)出對(duì)甘丙肽誘導(dǎo)的記憶缺陷的拮抗作用，具有減輕與阿爾茨海默病相關(guān)的認(rèn)知缺陷的潛力[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Vasopressor and tachycardia induced by galanin in Sprague-Dawley rats[1]
Dosage: 0.1-1 nmol
Administration: Intracisternal injection, single dose
Result: Blocked the feeding effects of galanin in the hypothalamus and amygdala.
Reduced vasopressor response and heart rate induced by galanin-(1-15), but not those effects induced by galanin-(1-29).
Animal Model: Memory impairment induced by galanin in rats model[2]
Dosage: 2-8 nmol
Administration: intraventricular or intrahippocampal, single dose
Result: Blocked the impairment in choice accuracy.
分子量

1980.31 (free base)

Formula

C95H146N22O24.xC2HF3O2
性狀

固體

Sequence

Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH2
Sequence Shortening

GWTLNSAGYLLGPPPALALA-NH2
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱(chēng)：
M40 TFA
目錄號(hào)：
HY-P1025A
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