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  2. Anti-infection
  3. RSV
  4. Motavizumab

Motavizumab  (Synonyms: 莫維珠單抗; MEDI-524)

目錄號(hào): HY-P99209 純度: 99.17%
COA 技術(shù)支持

Motavizumab (MEDI-524) 是一種 anti-human RSV (呼吸道合胞病毒) 單克隆抗體。Motavizumab 可用于高危嬰兒的呼吸道合胞病毒感染的研究。

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CAS No. : 677010-34-3

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規(guī)格 價(jià)格 是否有貨 數(shù)量
1 mg ￥3500
In-stock
5 mg ￥9600
In-stock
10 mg   詢價(jià)  
50 mg   詢價(jià)  

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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Motavizumab (MEDI-524) is an anti-human RSV (respiratory syncytial virus) monoclonal antibody. Motavizumab can be used in respiratory syncytial virus infection in high-risk infants research[1].

同型

Human IgG1(K214R) kappa
推薦同型對(duì)照抗體
IC50 & Target

RSV-F
體外研究
(In Vitro)

Motavizumab 在 F 蛋白啟動(dòng)與細(xì)胞膜相互作用后和病毒轉(zhuǎn)錄前顯示出活性[2]。
Motavizumab 抑制 F 蛋白介導(dǎo)的細(xì)胞間融合[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Motavizumab (腹膜內(nèi)注射；0.1 mL PBS 中 1.25 毫克/每只小鼠；一次) 處理顯示 RSV 感染小鼠的 RSV 復(fù)制以及細(xì)胞因子和趨化因子濃度降低[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Seven-week-old female, pathogen-free BALB/c mice intranasally inoculated with 106.5 PFU RSV-A2[1]
Dosage: 1.25 mg in 0.1 ml of PBS/per mouse
Administration: Intraperitoneal injection; 1.25 mg in 0.1 ml of PBS/per mouse; once
Result: Resulted in significant reductions of RSV loads compared with untreated controls on days 1 and 5.
Showed lower BAL concentrations of IL-1α, IL-12p70, TNF-α and IFN-γ and serum IL-10 and KC compared with RSV-infected untreated mice.
Clinical Trial
Accession

A0A0X8XRK2
應(yīng)用

ELISA, FACS, Functional assay
偶聯(lián)物

Unconjugated
復(fù)溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.32 kDa

CAS 號(hào)
性狀

液體

顏色

Colorless to light yellow

中文名稱

莫維珠單抗
運(yùn)輸條件

Shipping with dry ice.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human RSV (A2) Post-fusion glycoprotein F Protein (His Tag) can bind Motavizumab. The EC50 for this effect is 3.866 ng/mL.
純度 & 產(chǎn)品資料

純度: 99.17%

參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

產(chǎn)品名稱：
Motavizumab
目錄號(hào)：
HY-P99209
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