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Lenalidomide-5-aminomethyl hydrochloride

  Cat. No.:  DC51007   Featured
Chemical Structure
1158264-69-7
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Field of application
Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
Cas No.: 1158264-69-7
Chemical Name: Lenalidomide-5-aminomethyl hydrochloride
Synonyms: 3-(5-(aminomethyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride;3-[5-(aminomethyl)-1-oxo-2,3-dihydro-1H-isoindol-2-yl]piperidine-2,6-dione hydrochloride;3-[6-(aminomethyl)-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione;hydrochloride;D97252;A901902;3-(5-(amino methyl)-1-oxoisoindolin-2-yl)piperidine-2,6-dione hydrochloride;3-(5-(aminomethyl)-1-oxoisoindolin-2-yl) piperidine-2,6-dione hydrochloride;3-(5-aminomethyl-1-oxo-1,3;Lenalidomide-5-aminomethyl hydrochloride
SMILES: Cl[H].O=C1C2C([H])=C([H])C(C([H])([H])N([H])[H])=C([H])C=2C([H])([H])N1C1([H])C(N([H])C(C([H])([H])C1([H])[H])=O)=O
Formula: C14H16ClN3O3
M.Wt: 309.7481
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC.
Target: Cereblon
In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References: [1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
MSDS
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MSDS_27683_DC51007_1158264-69-7
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Cat. No. Product name Field of application
DC86101 VH032-cyclopropane-F E3 ligase Ligand 19 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 19 can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1]
DC51007 Lenalidomide-5-aminomethyl hydrochloride Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
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DC71103 Pomalidomide-PEG4-COOH Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1).
DC47216 Thalidomide-5,6-F Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
DC41134 Thalidomide-5-OH Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
DC12028 MDK7526(Protein degrader 1) MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.
DC11571 E3 Ligase Ligand 3 E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.
DC50061 Pomalidomide-C2-NH2(E3 ligase Ligand 17) E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
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