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  2. Membrane Transporter/Ion Channel Apoptosis
  3. ATP Synthase Apoptosis
  4. Apoptolidin

Apoptolidin 是從 Nocardiopsis 細菌中分離得到的一種聚酮類化合物。Apoptolidin 是一種選擇性線粒體 F1FO ATPase 抑制劑。Apoptolidin 是一種凋亡 (apoptosis)誘導(dǎo)劑，可誘導(dǎo)腺病毒型 12 癌基因(包括ElA) (IC50=10-17 ng/ml) 轉(zhuǎn)化的細胞凋亡，但不誘導(dǎo)正常細胞的凋亡。

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Apoptolidin Chemical Structure

Apoptolidin Chemical Structure

CAS No. : 194874-06-1

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規(guī)格 價格 是否有貨 數(shù)量
100 μg ￥6500
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  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻

生物活性

Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
NCI-H292 EC50
< 50 nM
Compound: 228
Cytotoxicity against human NCI-H292 cells assessed as reduction in cell viability incubated for 4 days by WST-1 assay
Cytotoxicity against human NCI-H292 cells assessed as reduction in cell viability incubated for 4 days by WST-1 assay
[PMID: 29126728]
NCI-H292 IC50
32 μM
Compound: Apoptolidin A
Anticancer activity against human NCI-H292 cells assessed as reduction in cell proliferation incubated for 48 hrs by Calcein AM and Pluronic F-127 staining based fluorescence plate reader analysis
Anticancer activity against human NCI-H292 cells assessed as reduction in cell proliferation incubated for 48 hrs by Calcein AM and Pluronic F-127 staining based fluorescence plate reader analysis
[PMID: 32942072]
體外研究
(In Vitro)

Apoptolidin has cytotoxicity against normal and transformed cells, it against RG-E1A-7,RG-E1A19K-2, RG-E1A54K-9, RG-E1-4 and Adl2-3Y1 with IC50 values of 11 ng/ml,10 ng/ml,13 ng/ml, 10 ng/ml and 17 ng/ml, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1129.37

Formula

C58H96O21
CAS 號
性狀

固體

顏色

White to off-white

結(jié)構(gòu)分類
初始來源

Nocardiopsis
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性數(shù)據(jù)
細胞實驗： 

DMSO 中的溶解度 : 1 mg/mL (0.89 mM; 超聲加熱助溶; 吸濕的 DMSO 對產(chǎn)品的溶解度有顯著影響，請使用新開封的 DMSO)

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純度 & 產(chǎn)品資料

純度: 95.6%

參考文獻
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Apoptolidin
目錄號：
HY-126679
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