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  2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. Synucleozid

Synucleozid (NSC 377363) 是可編碼 α-突觸核蛋白的 SNCA mRNA 的有效抑制劑。Synucleozid 選擇性靶向 α-synuclein mRNA 的 5'UTR 設計 IRE 位點，減少了加載到多核糖體中的 SNCA mRNA 的量，從而抑制了α-synuclein 蛋白的翻譯。Synucleozid 有潛力用于帕金森病的相關研究。

該游離形式化合物不穩(wěn)定，推薦具有相同生物學活性的穩(wěn)定鹽形式 Synucleozid hydrochloride。

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Synucleozid Chemical Structure

Synucleozid Chemical Structure

CAS No. : 502139-01-7

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  • 生物活性

  • 純度 & 產品資料

  • 參考文獻

生物活性

Synucleozid (NSC 377363) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease[1].

細胞效力
(Cellular Effect)
Cell Line Type Value Description References
CMK IC50
1.31 μM
Compound: K313
Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human CMK cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
[PMID: 34046601]
HEL IC50
2.27 μM
Compound: K313
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human HEL cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
[PMID: 34046601]
K562 IC50
1.08 μM
Compound: K313
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
[PMID: 34046601]
MEG-01 IC50
1.03 μM
Compound: K313
Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
Antiproliferative activity against human MEG-01 cells assessed as inhibition of cell growth measured after 72 hrs by CellTiter-Glo assay
[PMID: 34046601]
體外研究
(In Vitro)

Synucleozid (0.25-1 μM; 24 hours) abrogates cytotoxicity induced by α-synuclein preformed fibrils, which act as seeds and recruit endogenous α-synuclein to aggregate[1].
Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner with an IC50 of 500 nM, and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells[1].
Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission with an EC50 value of 2.7 ± 0.4 μM, recovery of 2-AP emissions is observed as a function of unlabeled SNCA IRE RNA (RNA-0) concentration, affording a competitive Kd of 1.5 ± 0.3 μM[1].
Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA’s UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 0.25 μM, 0.5 μM, 1 μM
Incubation Time: 24 hours
Result: Decreased LDH release as a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: SH-SY5Y neuroblastoma cells
Concentration: 0.25 μM; 0.5 μM; 1 μM;
Incubation Time: 24 hours
Result: Decreased α-synuclein expression as a concentration-dependent manner.
分子量

368.43

同用名

NSC 377363

Formula

C22H20N6
CAS 號
運輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產品資料
參考文獻

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  • 稀釋計算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產品名稱：
Synucleozid
目錄號：
HY-135902
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