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  2. GPCR/G Protein Neuronal Signaling
  3. mAChR
  4. Cevimeline

Cevimeline (AF-102B) 是一種乙酰膽堿的奎尼丁衍生物，也是一種選擇性的和口服活性的毒蕈堿型 M1 和 M3 受體激動(dòng)劑。Cevimeline 可刺激唾液腺分泌，并可用作口干癥的一種催涎劑。Cevimeline 可穿過(guò)血腦屏障。

在相同的摩爾濃度下，化合物鹽形式與游離形式有相同的生物活性，但鹽形式 Cevimeline hydrochloride hemihydrate 和 Cevimeline hydrochloride 通常具有更好的水溶性和穩(wěn)定性。

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Cevimeline Chemical Structure

Cevimeline Chemical Structure

CAS No. : 107233-08-9

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查看 mAChR 亞型特異性產(chǎn)品:

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

Cevimeline (AF-102B) is a quinuclidine derivative of acetylcholine and a selective and orally active muscarinic M1 and M3 receptor agonist. Cevimeline stimulates secretion by the salivary glands and can be used as a sialogogue for xerostomia[1][2][3][4]. Cevimeline can cross the blood-brain barrier (BBB)[5].

IC50 & Target

Muscarinic M1 and M3 receptor[1]
體外研究
(In Vitro)

In digested parotid cells, Cevimeline (0.1-100 μM) increases the intracellular Ca2+ concentration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
體內(nèi)研究
(In Vivo)

Cevimeline (0.008-0.016 mg/kg; intraperitoneal injection; male Wistar rats) treatment shows slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response. Cevimeline inhibits angiotensin II-induced water intake and neuronal activity in the subfornical organ at 0.016 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (8-week-old) injected with angiotensin-II[1]
Dosage: 0.008 mg/kg, 0.016 mg/kg
Administration: Intraperitoneal injection
Result: Showed slowly increasing and lasting salivation, and increased blood flow increment in the parotid gland and pressor response.
Clinical Trial
分子量

199.31

同用名

西維美林; AF102B

Formula

C10H17NOS
CAS 號(hào)
中文名稱

西維美林；西維米林
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲(chǔ)存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
純度 & 產(chǎn)品資料
參考文獻(xiàn)

  • 摩爾計(jì)算器

  • 稀釋計(jì)算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質(zhì)量   濃度   體積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

濃度 (start) × 體積 (start) = 濃度 (final) × 體積 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
Cevimeline
目錄號(hào)：
HY-70020
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