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Succimer

別名: DMSA, meso-2,3-dimercaptosuccinic acid 中文名稱：琥巰酸

目錄號：S4692 Purity: 99.51%

Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning.

Succimer Chemical Structure

CAS: 304-55-2

規(guī)格	價格	庫存
25mg	795.26	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次： S469201 DMSO]36 mg/mL]false]Ethanol]3 mg/mL]false]Water]Insoluble]false 純度： 99.51%

99.51

Succimer相關(guān)產(chǎn)品

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相關(guān)化合物庫	FDA藥物庫天然產(chǎn)物庫已知活性藥物庫-I 多樣性化合物母核庫	點擊展開

生物活性

產(chǎn)品描述	Succimer (DMSA, meso-2,3-dimercaptosuccinic acid) is an orally active metal chelator is used to treat heavy metal poisoning.

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試驗信息 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT03653702	Not yet recruiting	Vesico-Ureteral Reflux	Boston Children''s Hospital	October 1 2023	Phase 1
NCT05595863	Not yet recruiting	Brain Glioma	Assiut University	November 2022	--
NCT05593809	Not yet recruiting	Brain Glioma	Assiut University	October 2022	--
NCT04091685	Unknown status	Dimercaptosuccinic Acid SPECT and Planar	Assiut University	September 2019	--
NCT03959163	Recruiting	Pyelonephritis\|Pyelonephritis Acute\|Renal Sclerosis	University of Wisconsin Madison	May 7 2019	Not Applicable
NCT03879005	Unknown status	The Difference in Estimation of Split Renal Function Using the Two Radiopharmaceuticals:Tc-99m DTPA & Tc-99m DMSA in Kidney Patients	Assiut University	April 2019	Not Applicable

化學(xué)信息&溶解度

分子量	182.22	分子式	C₄H₆O₄S₂
CAS號	304-55-2	SDF	--
Smiles	C(C(C(=O)O)S)(C(=O)O)S
儲存條件(自收到貨起)	3年-20°C粉狀	儲備液保存和期限建議分裝儲備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲存條件(自收到貨起)	3年-20°C粉狀	儲備液保存和期限建議分裝儲備液，避免反復(fù)凍融！	1個月-20°C溶于溶劑

體外溶解度
批次：

DMSO : 36 mg/mL ( (197.56 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : 3 mg/mL (16.46 mM)

Water : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計算器分子量計算器

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

給藥劑量 mg/kg 動物平均體重 g 每只動物給藥體積 μL 動物數(shù)量只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進(jìn)行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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操作手冊

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* 必填項

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