Rabbit Anti-RAD50 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:RAD50
IR:Immunogen Range:817-872/1312
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:10111
Swiss Prot:Q92878
Source:KLH conjugated synthetic peptide derived from human RAD50:817-872/1312
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(0.2μg/Test)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Cow
Horse
Rabbit
Sheep
僅供科研使用。不能用于人和動物治療等其它臨床診斷用！
關鍵字： RAD50;DNA repair protein R;hRad50;hsRAD50;Mrell;NBSLD;RAD50 ;RAD50_HUMAN;
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