化合物 SSD114 hydrochloride|T4522|TargetMol

價(jià)格	￥497	￥1230	￥1990
包裝	1mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-07-28

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產(chǎn)品詳情

中文名稱:化合物 SSD114 hydrochloride	英文名稱:SSD114 HCl
CAS:2319790-02-6	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 97.83%	產(chǎn)品類別: 抑制劑
貨號: T4522

Product Introduction

Bioactivity

名稱	SSD114 HCl
描述	SSD114 is a novel GABAB receptor positive allosteric modulator.
細(xì)胞實(shí)驗(yàn)	Cells are transfected and seeded into 96-well microplates. 24 h after transfection, cells are washed twice with PBS and incubated in the presence or absence of SSD114 hydrochloride (different concentrations) for 15 min before substrate addition in a 96-well microplate. The Bioluminescence resonance energy transfer (BRET) ratio is calculated as the emission of YFP (530 to 570 nm) over the emission of RLuc (370 to 470 nm). The curves are fitted using Graph Pad Prism 5.0. The amplitude-weighted mean time constant is obtained by fitting the BRET recovery phase to a double exponential function [1].
動物實(shí)驗(yàn)	Male Sprague-Dawley rats and DBA mice, weighing 200 to 250 and 20 to 25 g, respectively, are used. On the test day, mice are divided into six groups (n=6 each) matched by body weight. Mice are treated acutely and intraperitoneally with 0, 1, 3, 10, 30, and 100 mg/kg SSD114 hydrochloride and sedation/hypnosis are measured. Specifically, after baclofen injection, each mouse is placed on its back once every 60 s until it is unable to right itself within 60 s. The time between baclofen injection and the start of the 60-s interval during which the mouse is unable to right itself is measured at the onset of loss of righting reflex (LORR). Each mouse is then left undisturbed on its back until it spontaneously regained its righting reflex (determined as having at least three paws under its body). Complete recovery of the righting reflex is defined as the mouse being able to turn itself upright twice more within 60 s. If this criterion is not fulfilled, the mouse is left undisturbed until it spontaneously regained its righting reflex. The time between loss and recovery of the righting reflex is monitored in each mouse and defined as the duration of LORR. Observations are conducted by an operator unaware of the drug treatment [1].
體外活性	在含有10μM GABA的條件下，25μM的SSD114 hydrochloride 顯著增加GABA單獨(dú)誘導(dǎo)的[35S]GTPγS激活水平，大約增至基礎(chǔ)水平的170%。SSD114 hydrochloride （15或30μM）引起GABA濃度-反應(yīng)曲線向左移動，并在最高濃度下輕微增加GABA的最大刺激效果。在15和30μM SSD114 hydrochloride 的共同存在下，GABA的EC50分別降低了2倍和2.5倍，而最大刺激效果（Emax）僅在30μM濃度下被增強(qiáng)，達(dá)到基礎(chǔ)值的161±5.09%[1]。
體內(nèi)活性	SSD114 hydrochloride預(yù)處理顯著縮短了失去翻正反射（LORR）的起始時(shí)間[F(5,30)=4.55, P<0.005]。后續(xù)分析表明，與對照組相比，接受等于或高于10 mg/kg SSD114 hydrochloride劑量預(yù)處理的小鼠組LORR起始時(shí)間顯著縮短。此外，SSD114 hydrochloride預(yù)處理延長了LORR的持續(xù)時(shí)間[F(5,30)=4.81, P<0.005]。后續(xù)分析指出，與對照組相比，接受10和100 mg/kg SSD114 hydrochloride預(yù)處理的小鼠組LORR持續(xù)時(shí)間顯著延長[1]。
存儲條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 45 mg/mL (116.03 mM), Sonication is recommended.
關(guān)鍵字	SSD-114 hydrochloride \| SSD-114 Hydrochloride \| SSD114 Hydrochloride \| SSD 114 Hydrochloride \| GABAReceptor \| GABAB \| GABA Receptor
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相關(guān)庫	經(jīng)典已知活性庫 \| 抗癌化合物庫 \| 已知活性化合物庫 \| 含氟化合物庫 \| 神經(jīng)信號分子庫 \| 離子通道庫 \| 膜蛋白靶向化合物庫 \| 神經(jīng)退行性疾病化合物庫 \| 疼痛相關(guān)化合物庫 \| 表型篩選靶點(diǎn)鑒定庫

關(guān)鍵字： SSD114 HCl|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓，致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國家和地區(qū)，已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫，以及多種類型的生化試劑產(chǎn)品，包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等，此外，我們還建設(shè)有CADD（計(jì)算機(jī)輔助藥物設(shè)計(jì)）研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺三大技術(shù)中心，全方位滿足客戶的定制需求。憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持，我們將有效幫助您縮短研發(fā)周期，取得更成功的結(jié)果。

成立日期	2013-04-18 （13年）	注冊資本	566.265100萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	天然產(chǎn)物,生化試劑,分子生物學(xué),分子砌塊,生物技術(shù)服務(wù)	經(jīng)營模式	貿(mào)易,工廠,試劑,定制,服務(wù)

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公司成立：13年
注冊資本：566.265100萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑、藥物篩選化合物庫、藥物篩選等
公司地址：靜安區(qū)江場三路238號8樓

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