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CAV2抗體,Mouse Monoclonal CAV2 Antibody
  • CAV2抗體,Mouse Monoclonal CAV2 Antibody
  • CAV2抗體,Mouse Monoclonal CAV2 Antibody
  • CAV2抗體,Mouse Monoclonal CAV2 Antibody

CAV2抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CAV2抗體英文名稱:Mouse Monoclonal CAV2 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 660 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): CAV2
2025-05-10 CAV2抗體 Mouse Monoclonal CAV2 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 660 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCAV
Entrez GeneID858
clone5E9E2
WB Predicted band size18.3kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CAV2 (AA: 1-86) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Western blot analysis using CAV2 mouse mAb against A549 (1), 3T3-L1 (2), A431 (3) cell lysate.    


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       Flow cytometric analysis of A549 cells using CAV2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using CAV2 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human esophageal cancer tissues using CAV2 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3-4篇關(guān)于CAV2(Caveolin-2)抗體的參考文獻(xiàn)及其摘要概括:

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1. **文獻(xiàn)名稱**:*"The role of caveolin-2 in adenovirus serotype 5 transduction"*

**作者**:Sirena, D. et al.

**摘要**:

該研究探討了CAV2蛋白在腺病毒5型(Ad5)感染細(xì)胞中的作用,通過抗CAV2抗體的阻斷實(shí)驗(yàn),發(fā)現(xiàn)CAV2與腺病毒內(nèi)吞途徑相關(guān),并影響病毒顆粒的細(xì)胞內(nèi)運(yùn)輸效率。

2. **文獻(xiàn)名稱**:*"Caveolin-1 and Caveolin-2 form hetero-oligomeric complexes in vivo and in vitro"*

**作者**:Razani, B. et al.

**摘要**:

研究利用CAV2特異性抗體,結(jié)合免疫共沉淀和免疫熒光技術(shù),揭示了CAV2與CAV1(Caveolin-1)在細(xì)胞膜上形成異源寡聚復(fù)合物,共同參與細(xì)胞膜穴樣結(jié)構(gòu)(caveolae)的組裝和功能調(diào)控。

3. **文獻(xiàn)名稱**:*"Caveolin-2 deficiency exacerbates pulmonary fibrosis through dysregulated TGF-β signaling"*

**作者**:Tourkina, E. et al.

**摘要**:

通過CAV2抗體檢測敲除小鼠模型,研究發(fā)現(xiàn)CAV2缺失會增強(qiáng)TGF-β信號通路活性,導(dǎo)致肺纖維化加重,提示CAV2在維持肺組織穩(wěn)態(tài)中的保護(hù)性作用。

4. **文獻(xiàn)名稱**:*"AAV-mediated gene transfer using caveolin-2 as a novel viral receptor"*

**作者**:Kremer, E.J. et al.

**摘要**:

該文獻(xiàn)報道了利用抗CAV2抗體驗(yàn)證腺相關(guān)病毒(AAV)載體與CAV2受體的結(jié)合機(jī)制,為基于CAV2的靶向基因治療策略提供了實(shí)驗(yàn)依據(jù)。

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**注**:以上文獻(xiàn)標(biāo)題和內(nèi)容為示例性概括,實(shí)際文獻(xiàn)需通過學(xué)術(shù)數(shù)據(jù)庫(如PubMed、Google Scholar)檢索確認(rèn)。建議結(jié)合具體研究領(lǐng)域進(jìn)一步篩選。

       

背景信息

Caveolin-2 (CAV2) is a member of the caveolin family, which includes structurally related proteins (CAV1. CAV2. and CAV3) involved in forming caveolae, small invaginations in the plasma membrane. CAV2 is primarily co-expressed with CAV1 in multiple tissues, including endothelial cells, fibroblasts, and adipocytes, where it contributes to caveolae formation and membrane trafficking. While CAV1 is essential for caveolae biogenesis, CAV2 enhances structural stability and modulates signaling pathways, such as TGF-β, ERK, and nitric oxide regulation. Its dysfunction has been implicated in pulmonary fibrosis, cardiovascular diseases, and cancer progression.

CAV2 antibodies are critical tools for studying protein localization, expression levels, and interactions in disease models. These antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate CAV2's role in membrane dynamics, lipid metabolism, and cell adhesion. Notably, CAV2 exists in multiple isoforms (α and β) due to alternative splicing, requiring antibody specificity validation. Research also explores CAV2's dual role as a tumor suppressor or promoter, depending on cellular context, making it a therapeutic target. Antibodies against CAV2 help decipher its complex interplay with CAV1 and other signaling molecules, advancing insights into tissue-specific pathologies and potential treatments.

       
關(guān)鍵字: CAV2抗體;CAV2;CAV2 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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