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MAPK7抗體,Mouse Monoclonal MAPK7 Antibody
  • MAPK7抗體,Mouse Monoclonal MAPK7 Antibody
  • MAPK7抗體,Mouse Monoclonal MAPK7 Antibody
  • MAPK7抗體,Mouse Monoclonal MAPK7 Antibody

MAPK7抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱(chēng):MAPK7抗體英文名稱(chēng):Mouse Monoclonal MAPK7 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 668 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類(lèi)別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): MAPK7
2025-05-10 MAPK7抗體 Mouse Monoclonal MAPK7 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 668 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBMK1; ERK4; ERK5; PRKM7
Entrez GeneID5598
clone8H1D5
WB Predicted band size88.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human MAPK7 (AA: 411-556) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide.

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       Black line: Control Antigen (100 ng); Purple line: Antigen(10ng); Blue line: Antigen (50 ng); Red line: Antigen (100 ng);    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using MAPK7 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human colon cancer tissues using MAPK7 mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是關(guān)于MAPK7(ERK5)抗體的3篇參考文獻(xiàn)示例(文獻(xiàn)名稱(chēng)、作者及摘要概括):

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1. **文獻(xiàn)名稱(chēng)**:*"ERK5/MAPK7 promotes tumorigenesis in triple-negative breast cancer via vascular mimicry"*

**作者**:Sawano et al. (2018)

**摘要**:研究利用MAPK7特異性抗體進(jìn)行Western blot和免疫組化,發(fā)現(xiàn)ERK5在乳腺癌中通過(guò)調(diào)控血管生成擬態(tài)促進(jìn)腫瘤侵襲,提示其作為潛在治療靶點(diǎn)。

2. **文獻(xiàn)名稱(chēng)**:*"ERK5 regulates endothelial cell apoptosis in atherosclerosis via NF-κB signaling"*

**作者**:Zheng et al. (2019)

**摘要**:通過(guò)MAPK7抗體敲低實(shí)驗(yàn),證明ERK5通過(guò)抑制NF-κB通路保護(hù)內(nèi)皮細(xì)胞凋亡,為動(dòng)脈粥樣硬化機(jī)制提供新見(jiàn)解。

3. **文獻(xiàn)名稱(chēng)**:*"MAPK7 antibody-based detection reveals its role in inflammatory bowel disease pathogenesis"*

**作者**:Chen et al. (2020)

**摘要**:利用抗MAPK7抗體進(jìn)行組織染色和流式分析,揭示ERK5在腸道炎癥中通過(guò)調(diào)控巨噬細(xì)胞極化加劇疾病進(jìn)展。

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*注:以上為示例文獻(xiàn),實(shí)際引用需核對(duì)真實(shí)論文信息。建議通過(guò)PubMed或Google Scholar搜索關(guān)鍵詞“MAPK7 antibody”“ERK5”獲取具體文獻(xiàn)。*

       

背景信息

The mitogen-activated protein kinase 7 (MAPK7), also known as extracellular signal-regulated kinase 5 (ERK5), is a member of the MAPK family involved in critical cellular processes such as proliferation, differentiation, and survival. Unlike other MAPKs, MAPK7 contains a unique C-terminal tail that regulates its activation and nuclear translocation. It is primarily activated by dual phosphorylation of threonine and tyrosine residues in the T-E-Y motif by upstream kinases like MEK5. MAPK7 plays a key role in stress responses, angiogenesis, and developmental pathways, with dysregulation linked to cancer, cardiovascular diseases, and neurodegenerative disorders.

MAPK7 antibodies are essential tools for detecting and studying the expression, localization, and activation status of MAPK7 in various biological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate MAPK7 signaling dynamics. Phospho-specific MAPK7 antibodies targeting the phosphorylated T-E-Y motif are particularly valuable for assessing its activation state. Research applications include exploring MAPK7's role in tumor progression, where its overexpression in certain cancers correlates with poor prognosis, or in cardiovascular studies examining its impact on endothelial cell function. Validating antibody specificity using knockout/knockdown controls is critical to ensure reliable experimental outcomes, as cross-reactivity with other MAPKs can occur. Overall, MAPK7 antibodies are pivotal for unraveling the protein's diverse physiological and pathological functions.

       
關(guān)鍵字: MAPK7抗體;MAPK7;MAPK7 Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
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  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類(lèi)型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤(pán)

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