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HTR3B抗體,Mouse Monoclonal HTR3B Antibody
  • HTR3B抗體,Mouse Monoclonal HTR3B Antibody
  • HTR3B抗體,Mouse Monoclonal HTR3B Antibody
  • HTR3B抗體,Mouse Monoclonal HTR3B Antibody

HTR3B抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:HTR3B抗體英文名稱:Mouse Monoclonal HTR3B Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 995 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點: HTR3B
2025-05-10 HTR3B抗體 Mouse Monoclonal HTR3B Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 995 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC1/100 - 1/500 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

Aliases5-HT3B
Entrez GeneID9177
clone2H9H5
WB Predicted band size50.3kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human HTR3B (AA: extra 23-150) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using HTR3B mouse mAb against SK-N-SH (1) and Hela (2) cell lysate.    


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       Immunofluorescence analysis of Hela cells using HTR3B mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)    


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       Flow cytometric analysis of Hela cells using HTR3B mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下是3篇關(guān)于HTR3B抗體的示例參考文獻(xiàn)(注:內(nèi)容為模擬虛構(gòu),僅用于示例格式):

1. **文獻(xiàn)名稱**: "Selective binding and functional characterization of a human HTR3B-specific monoclonal antibody in neuropsychiatric disorders"

**作者**: Müller, A., et al.

**摘要**: 研究報道了一種高選擇性HTR3B單克隆抗體的開發(fā),通過免疫組化證實其在精神分裂癥患者前額葉皮層中的表達(dá)顯著降低,提示HTR3B可能與5-HT信號通路異常相關(guān)。

2. **文獻(xiàn)名稱**: "HTR3B antibody-based detection of receptor complexes in enteric neurons and implications for irritable bowel syndrome"

**作者**: Chen, L., et al.

**摘要**: 利用HTR3B多克隆抗體揭示了腸道神經(jīng)元中HTR3A/HTR3B異源五聚體的分布,發(fā)現(xiàn)腸易激綜合征患者結(jié)腸組織中HTR3B表達(dá)上調(diào),可能參與內(nèi)臟高敏感機制。

3. **文獻(xiàn)名稱**: "Structural insights into HTR3B extracellular domain using cryo-EM and targeted antibody labeling"

**作者**: Zhang, Y., et al.

**摘要**: 通過冷凍電鏡技術(shù)結(jié)合HTR3B特異性抗體標(biāo)記,解析了HTR3B胞外結(jié)構(gòu)域的構(gòu)象變化,為設(shè)計靶向該亞基的神經(jīng)調(diào)節(jié)藥物提供了結(jié)構(gòu)基礎(chǔ)。

4. **文獻(xiàn)名稱**: "HTR3B autoantibodies in autoimmune encephalitis: Clinical correlations and diagnostic potential"

**作者**: Tanaka, R., et al.

**摘要**: 首次報道了針對HTR3B的自身抗體在一組自身免疫性腦炎患者血清中的存在,抗體陽性患者表現(xiàn)出顯著的焦慮和胃腸功能障礙,提示外周與中樞HTR3B通路的交叉作用。

(注:實際文獻(xiàn)需通過PubMed/Google Scholar等平臺以“HTR3B antibody”為關(guān)鍵詞檢索獲取。)

       

背景信息

The HTR3B antibody targets the 5-hydroxytryptamine receptor 3B (HTR3B), a subunit of the serotonin-gated ion channel 5-HT3 receptor. This receptor, part of the Cys-loop ligand-gated ion channel family, mediates rapid synaptic transmission in the central and peripheral nervous systems. While the 5-HT3 receptor typically functions as a pentamer, HTR3B cannot form homomeric channels and instead combines with HTR3A to create heteromeric complexes. These heteroreceptors exhibit distinct pharmacological and electrophysiological properties compared to homomeric HTR3A receptors, including altered serotonin sensitivity and ion conductance.

HTR3B antibodies are essential tools for studying receptor expression, localization, and function in research contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and flow cytometry to investigate HTR3B distribution in tissues, particularly in the gastrointestinal tract and brain regions involved in emesis, mood regulation, and pain processing. Dysregulation of HTR3B has been implicated in conditions such as irritable bowel syndrome (IBS), chemotherapy-induced nausea, and psychiatric disorders, making these antibodies valuable for both mechanistic studies and drug development. Commercially available HTR3B antibodies are typically validated for specificity against recombinant proteins or native tissues, though variability in subunit assembly and tissue-specific glycosylation patterns requires careful experimental optimization.

       
關(guān)鍵字: HTR3B抗體;HTR3B;HTR3B Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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