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BCL9L抗體,Mouse Monoclonal BCL9L Antibody
  • BCL9L抗體,Mouse Monoclonal BCL9L Antibody
  • BCL9L抗體,Mouse Monoclonal BCL9L Antibody
  • BCL9L抗體,Mouse Monoclonal BCL9L Antibody

BCL9L抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:BCL9L抗體英文名稱:Mouse Monoclonal BCL9L Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 996 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 靶點(diǎn): BCL9L
2025-05-10 BCL9L抗體 Mouse Monoclonal BCL9L Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 996 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC咨詢技術(shù) Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesBCL9-2; DLNB11
Entrez GeneID283149
clone1C9G2
WB Predicted band size157kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human BCL9L (AA: 606-751) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Hela cells using BCL9L mouse mAb (green) and negative control (red).    


           

參考文獻(xiàn)

以下是關(guān)于BCL9L抗體的3篇示例參考文獻(xiàn)(注:以下內(nèi)容為模擬示例,非真實(shí)文獻(xiàn)):

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**1. 文獻(xiàn)名稱**: *BCL9L Antibody-Mediated Wnt/β-Catenin Pathway Inhibition Suppresses Colorectal Cancer Progression*

**作者**: Smith J, et al.

**摘要**: 本研究開發(fā)了一種針對BCL9L蛋白的單克隆抗體,通過阻斷其與β-catenin的相互作用,顯著抑制Wnt信號通路活性。在結(jié)直腸癌小鼠模型中,該抗體有效減少腫瘤生長和轉(zhuǎn)移,提示其作為靶向治療的潛力。

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**2. 文獻(xiàn)名稱**: *A Novel BCL9L-Specific Antibody for Immunohistochemical Detection in Solid Tumors*

**作者**: Chen L, et al.

**摘要**: 報(bào)道了一種高特異性BCL9L抗體,優(yōu)化用于福爾馬林固定石蠟包埋組織的免疫組化檢測。該抗體在肝癌和胰腺癌樣本中顯示BCL9L過表達(dá),且表達(dá)水平與患者預(yù)后呈負(fù)相關(guān),為癌癥診斷提供新工具。

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**3. 文獻(xiàn)名稱**: *Targeting BCL9L in T-cell Acute Lymphoblastic Leukemia with a Humanized Antibody*

**作者**: Rodriguez M, et al.

**摘要**: 研究構(gòu)建了人源化抗BCL9L抗體,在T-ALL細(xì)胞系中證實(shí)其可通過下調(diào)Wnt靶基因誘導(dǎo)凋亡。聯(lián)合化療使用時,顯著增強(qiáng)白血病細(xì)胞清除效率,為血液腫瘤治療提供新策略。

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如需真實(shí)文獻(xiàn),建議通過PubMed或Google Scholar以“BCL9L antibody”或“BCL9L therapeutic targeting”為關(guān)鍵詞檢索近年研究。

       

背景信息

The BCL9L (B-cell lymphoma 9-like) protein is a key regulatory component of the Wnt/β-catenin signaling pathway, which plays critical roles in embryonic development, tissue homeostasis, and cancer progression. BCL9L, along with its homolog BCL9. acts as a transcriptional coactivator by facilitating the nuclear translocation of β-catenin and enhancing its interaction with TCF/LEF transcription factors to drive target gene expression. Dysregulation of this pathway, particularly through BCL9L overexpression or mutations, has been implicated in various cancers, including colorectal, hepatocellular, and hematological malignancies.

BCL9L-specific antibodies are essential tools for studying its expression, localization, and functional interactions in both physiological and pathological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation to investigate BCL9L’s role in tumorigenesis and metastasis. Research has highlighted BCL9L as a potential therapeutic target, as its inhibition can disrupt β-catenin-dependent oncogenic signaling without severely affecting normal Wnt pathway functions. Additionally, studies using BCL9L antibodies have explored its involvement in immune modulation and stem cell maintenance, underscoring its multifaceted contributions to disease mechanisms. The development of selective BCL9L antibodies continues to advance precision oncology efforts, particularly in cancers driven by Wnt pathway hyperactivity.

       
關(guān)鍵字: BCL9L抗體;BCL9L;BCL9L Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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