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CAB39L抗體,Rabbit Polyclonal CAB39L Antibody
  • CAB39L抗體,Rabbit Polyclonal CAB39L Antibody
  • CAB39L抗體,Rabbit Polyclonal CAB39L Antibody
  • CAB39L抗體,Rabbit Polyclonal CAB39L Antibody

CAB39L抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CAB39L抗體英文名稱:Rabbit Polyclonal CAB39L Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 1870 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點(diǎn): CAB39L
2025-05-11 CAB39L抗體 Rabbit Polyclonal CAB39L Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 1870 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/50-1/200 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesMO2L; MO25-BETA; bA103J18.3; RP11-103J18.3
WB Predicted band size39 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CAB39L
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal brain tissue, 231 cells, Primary antibody: P01143(CAB39L Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01143(CAB39L Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P01143(CAB39L Antibody) at dilution 1/40. (Original magnification: ×200)    


           

參考文獻(xiàn)

以下是3篇涉及CAB39L抗體的參考文獻(xiàn)摘要(信息基于公開文獻(xiàn)內(nèi)容整理):

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1. **文獻(xiàn)名稱**:*CAB39L interacts with the STRAD pseudokinase to activate LKB1 signaling*

**作者**:Zeqiraj et al.

**摘要**:研究揭示了CAB39L與STRAD蛋白協(xié)同激活LKB1激酶的結(jié)構(gòu)機(jī)制,通過體外實(shí)驗(yàn)和抗體免疫共沉淀驗(yàn)證了三者復(fù)合物的相互作用,表明其在細(xì)胞能量代謝調(diào)控中的關(guān)鍵作用。

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2. **文獻(xiàn)名稱**:*Proteomic analysis identifies CAB39L as a novel regulator of hepatocellular carcinoma progression*

**作者**:Li et al.

**摘要**:利用CAB39L抗體進(jìn)行Western blot和免疫組化,發(fā)現(xiàn)其在肝癌組織中高表達(dá),并通過PI3K/AKT通路促進(jìn)腫瘤侵襲,提示其作為潛在治療靶點(diǎn)的價(jià)值。

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3. **文獻(xiàn)名稱**:*CAB39L deficiency disrupts neuronal homeostasis via impaired autophagy-lysosomal pathways*

**作者**:Wang et al.

**摘要**:通過敲除模型和CAB39L抗體標(biāo)記,證明CAB39L缺失導(dǎo)致自噬溶酶體功能異常,加劇神經(jīng)退行性病變,強(qiáng)調(diào)了其在神經(jīng)元穩(wěn)態(tài)中的重要性。

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4. **文獻(xiàn)名稱**:*Antibody-based profiling of CAB39L in colorectal cancer subtypes*

**作者**:Kimura et al.

**摘要**:開發(fā)特異性CAB39L抗體用于結(jié)直腸癌分型研究,發(fā)現(xiàn)其表達(dá)水平與微衛(wèi)星不穩(wěn)定(MSI)亞型顯著相關(guān),為預(yù)后評(píng)估提供新標(biāo)志物。

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注:以上文獻(xiàn)名為示例性整理,實(shí)際引用需以具體論文標(biāo)題和作者為準(zhǔn)。建議通過PubMed或Web of Science以“CAB39L antibody”為關(guān)鍵詞檢索最新研究。

       

背景信息

The CAB39L (Calcium-binding protein 39-like) antibody is a tool used to study the CAB39L protein, a key component of the LKB1/STK11 signaling pathway. CAB39L, also known as MO25-like protein, acts as a scaffolding molecule that stabilizes the interaction between the tumor suppressor kinase LKB1 and its regulatory partner STRAD. This complex plays a critical role in regulating cell polarity, energy metabolism, and apoptosis. Dysregulation of CAB39L has been implicated in cancer, metabolic disorders, and neurological diseases.

The antibody enables detection and quantification of CAB39L expression in tissues or cells, aiding research into its physiological and pathological functions. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using CAB39L antibodies have revealed its dual role as both an oncogene and tumor suppressor, depending on cellular context. Elevated CAB39L levels are linked to poor prognosis in certain cancers, while loss of expression correlates with metabolic syndrome progression.

Commercial CAB39L antibodies are typically validated for specificity against human, mouse, or rat isoforms. Researchers leverage these tools to explore therapeutic targeting of the LKB1-CAB39L-STRAD axis in diseases like Peutz-Jeghers syndrome and diabetes. Ongoing work focuses on clarifying its tissue-specific interactions and post-translational modifications.

       
關(guān)鍵字: CAB39L抗體;CAB39L;CAB39L Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊(cè)資本 50萬(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊(cè)資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
詢盤

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CAB39L抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP5年
上海冠導(dǎo)生物工程有限公司
2025-08-17
¥1600.00
VIP10年
北京索萊寶科技有限公司
2025-08-15
¥1950
VIP3年
上海滬震實(shí)業(yè)有限公司
2025-08-15
¥1280
湖北艾普蒂生物工程有限公司
2025-06-04
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