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VGF抗體,Rabbit Polyclonal VGF Antibody
  • VGF抗體,Rabbit Polyclonal VGF Antibody
  • VGF抗體,Rabbit Polyclonal VGF Antibody
  • VGF抗體,Rabbit Polyclonal VGF Antibody

VGF抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-12
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:VGF抗體英文名稱:Rabbit Polyclonal VGF Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2869 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: VGF
2025-05-12 VGF抗體 Rabbit Polyclonal VGF Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2869 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/30-1/150 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

WB Predicted band size67 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human VGF
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Raw264.7 cells, Primary antibody: P05505(VGF Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P05505(VGF Antibody) at dilution 1/45. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain tissue using P05505(VGF Antibody) at dilution 1/45. (Original magnification: ×200)    


           

參考文獻

以下是3篇與VGF抗體相關(guān)的代表性文獻摘要:

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1. **文獻名稱**:*VGF is required for obesity induced by diet, gold thioglucose treatment, and agouti and is differentially regulated in pro-opiomelanocortin- and neuropeptide Y-containing arcuate neurons in response to fasting*

**作者**:Hahm S, et al.

**摘要**:該研究利用VGF基因敲除小鼠模型,結(jié)合VGF特異性抗體檢測,發(fā)現(xiàn)VGF在中樞能量平衡調(diào)節(jié)中起關(guān)鍵作用??贵w免疫組化顯示VGF在下丘腦POMC神經(jīng)元中高表達,且其表達水平受攝食狀態(tài)調(diào)控。

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2. **文獻名稱**:*TLQP-21. a VGF-derived peptide, enhances energy expenditure and reverses diet-induced obesity through peripheral β-adrenergic receptor signaling*

**作者**:Bartolomucci A, et al.

**摘要**:研究聚焦于VGF衍生肽TLQP-21的代謝調(diào)控功能。通過VGF抗體的免疫中和實驗,證實TLQP-21通過激活β-腎上腺素能受體促進脂肪分解和產(chǎn)熱,為肥胖治療提供了新靶點。

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3. **文獻名稱**:*Antibody-based detection of VGF peptides in endocrine cells and neuronal projections*

**作者**:Possenti R, et al.

**摘要**:開發(fā)了特異性識別VGF羧基端肽段的單克隆抗體,驗證了其在腦組織和外周內(nèi)分泌細胞中的定位效能??贵w成功應用于免疫印跡和免疫熒光,揭示了VGF在神經(jīng)內(nèi)分泌信號中的廣泛分布。

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這些研究均通過VGF抗體的實驗手段,揭示了該神經(jīng)肽在代謝調(diào)控、能量平衡及神經(jīng)信號傳導中的關(guān)鍵作用。如需具體文獻鏈接,建議在PubMed或Web of Science平臺通過標題檢索。

       

背景信息

VGF (non-acronymic) is a neurosecretory protein initially identified as a nerve growth factor-responsive transcript in sensory neurons. It encodes a precursor protein that undergoes proteolytic cleavage to generate multiple bioactive peptides, including TLQP-62. NERP-1/2. and AQEE-30. implicated in energy homeostasis, pain modulation, and neuroendocrine regulation. VGF-derived peptides are widely expressed in the central and peripheral nervous systems, endocrine cells, and metabolic tissues.

VGF antibodies are essential tools for detecting VGF protein or its processed peptides in research. They enable the investigation of VGF's roles in neuroplasticity, stress response, and metabolic disorders. These antibodies are commonly used in techniques like Western blotting, immunohistochemistry, and ELISA to map VGF expression patterns in brain regions (e.g., hypothalamus, hippocampus) and peripheral tissues.

Studies utilizing VGF antibodies have linked altered VGF levels to depression, schizophrenia, Alzheimer’s disease, and metabolic syndromes. For example, reduced hippocampal VGF correlates with cognitive deficits, while its overexpression in adipose tissue influences insulin sensitivity. Commercially available VGF antibodies often target specific epitopes (e.g., C-terminal regions), but validation via knockout controls is critical due to potential cross-reactivity with structurally similar peptides. Emerging applications include exploring VGF as a biomarker or therapeutic target for neuropsychiatric and metabolic diseases.

       
關(guān)鍵字: VGF抗體;VGF;VGF Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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