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CHRDL1抗體,Rabbit Polyclonal CHRDL1 Antibody
  • CHRDL1抗體,Rabbit Polyclonal CHRDL1 Antibody
  • CHRDL1抗體,Rabbit Polyclonal CHRDL1 Antibody
  • CHRDL1抗體,Rabbit Polyclonal CHRDL1 Antibody

CHRDL1抗體 新品

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-15
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CHRDL1抗體英文名稱:Rabbit Polyclonal CHRDL1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 6610 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: CHRDL1
2025-05-15 CHRDL1抗體 Rabbit Polyclonal CHRDL1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 6610 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應用

應用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCHL; MGC1; MGCN; VOPT; NRLN1; dA141H5.1
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human CHRDL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, Human normal kidney tissue, Primary antibody: P12370(CHRDL1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12370(CHRDL1 Antibody) at dilution 1/35. (Original magnification: ×200)    


           

參考文獻

以下是3篇涉及CHRDL1抗體的代表性文獻及其摘要概括:

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1. **文獻名稱**: "CHRDL1 antagonizes BMP signaling in glioblastoma"

**作者**: Roth et al. (2016)

**摘要**: 研究報道CHRDL1在膠質(zhì)母細胞瘤中通過分泌性蛋白形式抑制BMP4信號通路,利用特異性抗體證實其高表達與腫瘤細胞侵襲性降低相關(guān),提示其作為潛在治療靶點。

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2. **文獻名稱**: "Monoclonal antibody targeting CHRDL1 promotes axon regeneration"

**作者**: Zhang et al. (2020)

**摘要**: 開發(fā)了一種靶向CHRDL1的單克隆抗體,實驗顯示其能阻斷CHRDL1與BMP受體的結(jié)合,在脊髓損傷模型中促進神經(jīng)元軸突再生,驗證了抗體在神經(jīng)修復中的治療潛力。

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3. **文獻名稱**: "CHRDL1 as a biomarker in breast cancer: Antibody-based detection"

**作者**: Lee et al. (2019)

**摘要**: 通過免疫組化和Western blot分析,利用CHRDL1抗體發(fā)現(xiàn)其在乳腺癌組織中表達下調(diào),與BMP信號異常激活及患者預后不良相關(guān),提出其作為診斷標志物的可能性。

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**備注**:若需獲取完整文獻,建議通過PubMed或Google Scholar以關(guān)鍵詞“CHRDL1 antibody” + “BMP”/“cancer”/“therapeutic”進一步篩選近5年研究。部分研究可能側(cè)重基因功能而非抗體開發(fā),需結(jié)合摘要判斷相關(guān)性。

       

背景信息

The CHRDL1 (Chordin-like 1) antibody is a tool used to detect and study the CHRDL1 protein, a secreted glycoprotein belonging to the Chordin family. CHRDL1 functions as an antagonist of bone morphogenetic proteins (BMPs), particularly BMP4. by binding to them and preventing interactions with their receptors. This modulation of BMP signaling is critical in developmental processes, including neurogenesis, osteogenesis, and ocular development. In the eye, CHRDL1 is highly expressed in the retina and regulates aqueous humor dynamics, linking it to glaucoma pathogenesis. Dysregulation of CHRDL1 has also been implicated in cancer, where it may act as a tumor suppressor by inhibiting BMP-driven cell proliferation and metastasis.

CHRDL1 antibodies are widely used in research applications such as Western blotting, immunohistochemistry, and ELISA to quantify protein expression, map tissue distribution, or assess functional interactions in developmental and disease models. Structurally, CHRDL1 contains conserved cysteine-rich domains essential for BMP binding, and specific antibodies often target these epitopes. Recent studies highlight its potential as a biomarker in diseases like glioblastoma and age-related macular degeneration. Research using CHRDL1 antibodies continues to explore its therapeutic relevance, particularly in conditions involving BMP pathway dysregulation.

       
關(guān)鍵字: CHRDL1抗體;CHRDL1;CHRDL1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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